Can the tongue microbiome help diagnose pancreatic cancer?

| January 29, 2019

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Pancreatic cancer is typically an aggressive form of the disease, with a fairly low 5-year survival rate. Diagnosing pancreatic cancer in its early stages could help people receive treatment more quickly, but what kind of test would work best? The National Cancer Institute (NCI) reports that approximately 1.6 percent of adults in the United States will receive a pancreatic cancer diagnosis during their lifetime.

Spotlight

PooyaGene Biotech Co.

PooyaGene Biotech Company is a research- and knowledge-driven enterprise. The company commenced its operation as a R&D unit in 2007, set up by some talented Iranian professionals to settle a state-of-the-art company to offer the high quality production and services in Biotechnology and Bioinformatics. In 2009, the R&D unit successfully qualified to pursue its activity in a Science and Technology Incubator Center in Iran. PooyaGene Biotech Company - Officially registered in 2010- later in 2011, to expand its collaboration with overseas pharmaceutical and biotech companies started its business operation in India.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

PooyaGene Biotech Co.

PooyaGene Biotech Company is a research- and knowledge-driven enterprise. The company commenced its operation as a R&D unit in 2007, set up by some talented Iranian professionals to settle a state-of-the-art company to offer the high quality production and services in Biotechnology and Bioinformatics. In 2009, the R&D unit successfully qualified to pursue its activity in a Science and Technology Incubator Center in Iran. PooyaGene Biotech Company - Officially registered in 2010- later in 2011, to expand its collaboration with overseas pharmaceutical and biotech companies started its business operation in India.

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