Biotech Showcase™ 2016: Interview: Diagnostics company VisionGate migrates into therapeutics

EBD GROUP | February 9, 2016

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VisionGate founder, chairman and CEO Dr. Alan Nelson explains to Mike Ward, Informa Pharma Insights global director of content, what has motivated the company to migrate from being a diagnostics business to one having a therapeutics focus. Having developed a non-invasive test for lung cancer, LuCED, which also has indicated an ability to detect various tumor types and stages of lung cancer, including Stage I and even dysplasia, VisionGate acquired exclusive rights to the University of Colorado’s patent for the use of the drug Iloprost, a drug currently used to treat various lung diseases such as pulmonary arterial hypertension, in the prevention of lung cancer.

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Pfizer, BioNTech Plan Clinical Trial for COVID-19 mRNA Vaccine Candidate

Article | April 9, 2020

Pfizer and BioNTech plan to begin human clinical trials on their lead COVID-19 therapeutic candidate, an mRNA vaccine, by the end of this month, the companies said today, through a collaboration that could generate up to $748 million for the German biotech. The companies announced plans last month to partner on BNT162, the first treatment to emerge from BioNTech’s accelerated COVID-19-focused development program, “Project Lightspeed.” BioNTech and Pfizer established collaboration intended to draw upon BioNTech’s proprietary mRNA vaccine platforms, and Pfizer’s expertise in vaccine research and development, regulatory capabilities, and global manufacturing and distribution network.

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Closing bacterial genomes from the human gut microbiome using long-read sequencing

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In our lab, we focus on the impact of the gut microbiome on human health and disease. To evaluate this relationship, it’s important to understand the particular functions that different bacteria have. As bacteria are able to exchange, duplicate, and rearrange their genes in ways that directly affect their phenotypes, complete bacterial genomes assembled directly from human samples are essential to understand the strain variation and potential functions of the bacteria we host. Advances in the microbiome space have allowed for the de novo assembly of microbial genomes directly from metagenomes via short-read sequencing, assembly of reads into contigs, and binning of contigs into putative genome drafts. This is advantageous because it allows us to discover microbes without culturing them, directly from human samples and without reference databases. In the past year, there have been a number of tour de force efforts to broadly characterize the human gut microbiota through the creation of such metagenome-assembled genomes (MAGs)[1–4]. These works have produced hundreds of thousands of microbial genomes that vastly increase our understanding of the human gut. However, challenges in the assembly of short reads has limited our ability to correctly assemble repeated genomic elements and place them into genomic context. Thus, existing MAGs are often fragmented and do not include mobile genetic elements, 16S rRNA sequences, and other elements that are repeated or have high identity within and across bacterial genomes.

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Article | April 13, 2020

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Selexis Cell Line Development Strategies

Article | February 11, 2020

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RxSalesPros is a national Pharmaceutical and Biotechnology recruiting firm exclusively dedicated to helping Startups and Fortune 100 Pharmaceutical and Biotech companies build the best sales force. In our 15 years in business, we've recruited over 6000 Sales Reps and Sales Leaders and helped over 50 Startups and Fortune 100 Pharmaceutical companies commercialize, expand and retool their approach on how to build a world class sales force.

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