Backup and Disaster Recovery as a Service: Driving New Data Protection Opportunities for Healthcare Organizations

| August 15, 2018

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The data protection market is highly dynamic, driven by new application workload deployments and cloud capabilities. Healthcare organizations are embracing cloud computing and are more willing to move certain workloads, such as IT operations, to the cloud. Healthcare IT executives acknowledge that managed service providers know more about data center security than their own organizations, especially when it comes to cybersecurity.

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SMALTIS

SMALTIS is a company created by two young doctors of Bacteriology, Sophie Guénard and Cédric Muller, and its mission is assisting public and private research laboratories in carrying out their projects. Various individualised services in bacteriology and molecular biology are available, from producing inactivation mutants to determining the levels of resistance to all types of drugs through the construction of vectors or production of plasmids.

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Selexis Cell Line Development Strategies

Article | February 11, 2020

In today’s biotechnology landscape, to be competitive, meet regulations, and achieve market demands, “we must apply Bioprocessing 4.0,” said Igor Fisch, PhD, CEO, Selexis. In fact, in the last decade, “Selexis has evolved from cloning by limiting dilution to automated cell selection to nanofluidic chips and from monoclonality assessment by statistical calculation to proprietary bioinformatic analysis,” he added. Single-use processing systems are an expanding part of the biomanufacturing world; as such, they are a major component of Bioprocessing 4.0. “At Selexis, we use single use throughout our cell line development workflow. Currently, we have incorporated single-use automated bioprocessing systems such as ambr® and the Beacon® optofluidic platform for accelerated cell line development. By using these systems and optimizing our parameters, we were able to achieve high titers in shake flasks. Additionally, the Beacon systems integrate miniaturized cell culture with high-throughput liquid handling automation and cell imaging. This allows us to control, adjust, and monitor programs at the same time,” noted Fisch.

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Learning How FoxA2 Helps Turn Stem Cells into Organs

Article | February 11, 2020

Scientists at the Perelman School of Medicine at the University of Pennsylvania discovered early on in each cell, FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation. The discovery, “Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones,” published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs, according to the researchers. “Gene network transitions in embryos and other fate-changing contexts involve combinations of transcription factors. A subset of fate-changing transcription factors act as pioneers; they scan and target nucleosomal DNA and initiate cooperative events that can open the local chromatin. However, a gap has remained in understanding how molecular interactions with the nucleosome contribute to the chromatin-opening phenomenon,” write the investigators.

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Cell Out? Lysate-Based Expression an Option for Personalized Meds

Article | February 11, 2020

Cell-free expression (CFE) is the practice of making a protein without using a living cell. In contrast with cell line-based methods, production is achieved using a fluid containing biological components extracted from a cell, i.e., a lysate. CFE offers potential advantages for biopharma according to Philip Probert, PhD, a senior scientist at the Centre for Process Innovation in the U.K.

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Ruminating on Bioprocessing 4.0

Article | February 11, 2020

The Bioprocessing 4.0 concept seeks to apply automation and technology to the digital transformation of biologics manufacturing. As the paradigm moves forward, it faces barriers to its adoption, according to Eric Langer, president of BioPlan Associates. “Perhaps the greatest challenges involve unsecured links and adapting the applications to areas where automation is critically needed today,” says Langer. “Unresolved security issues could seriously affect a company’s data in a regulated environment, so they will need to have iron-clad anti-hacking protection in place. Unfortunately, cyber security is not yet a top focus for the industry.”

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Spotlight

SMALTIS

SMALTIS is a company created by two young doctors of Bacteriology, Sophie Guénard and Cédric Muller, and its mission is assisting public and private research laboratories in carrying out their projects. Various individualised services in bacteriology and molecular biology are available, from producing inactivation mutants to determining the levels of resistance to all types of drugs through the construction of vectors or production of plasmids.

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