ASSESSING DRUG TARGET ASSOCIATION FROM BIOLOGICAL EVIDENCE

| April 5, 2018

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A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis (RA)1. Here we performed a genome-wide association study meta-analysis in a total of  subjects of European and Asian ancestries , by evaluating  million single-nucleotide polymorphisms.

Spotlight

Orbit Biotech

Estd in 2006, Orbit Biotech is a flagship biotech division of Zodiac Brand Space Pvt. Ltd. an ISO 9001:2008 certified company. The company is focussed on its research in Probiotics and the team has successfully completed many research projects funded by Department of Biotechnology (DBT), Govt. of India. Several in-house research projects aiming at developing state of the art probiotic applications are under process. The company is pioneer in training biotech students and professionals aiming at creating a skilled biotech professionals though its programs. Our aspiration is to provide biotechnology solutions by finding better methods of applications and work actively to promote collaborations between all parties in biotechnological industry in order to achieve our common goal of global competence. Our research and technology leads to the discovery of new and innovative products.

OTHER ARTICLES
MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

Orbit Biotech

Estd in 2006, Orbit Biotech is a flagship biotech division of Zodiac Brand Space Pvt. Ltd. an ISO 9001:2008 certified company. The company is focussed on its research in Probiotics and the team has successfully completed many research projects funded by Department of Biotechnology (DBT), Govt. of India. Several in-house research projects aiming at developing state of the art probiotic applications are under process. The company is pioneer in training biotech students and professionals aiming at creating a skilled biotech professionals though its programs. Our aspiration is to provide biotechnology solutions by finding better methods of applications and work actively to promote collaborations between all parties in biotechnological industry in order to achieve our common goal of global competence. Our research and technology leads to the discovery of new and innovative products.

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