10 Hot European Biotechs to Observe in 2017

| January 3, 2017

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BioNTech is Europe’s largest private Biotech with over 500 employees and is one of the three leading mRNA therapy companies in the world alongside CureVac and the money-magnet Moderna. At the end of 2016, it announced the biggest Biotech deal ever signed in Europe with Genentech: €280M upfront and a 50/50 split on profits. The total size of the deal hasn’t been made public but I heard from our sources that it is massive. The rest of the pipeline is also very promising and 2017 will be a turning point for the company and for the whole mRNA field, which is still in its early days and lacking advanced clinical data.

Spotlight

Sengkang Health

Sengkang Health forms a vital part of Singapore’s master plan in providing innovative, quality and accessible healthcare to our vibrant island nation of over five million people. Nestled in the northeast heartland, it will offer cutting-edge general hospital competencies with community-based care. As a member of SingHealth, Singapore’s largest academic healthcare cluster, Sengkang General and Community Hospitals will augment SingHealth’s infrastructure in delivering a full spectrum of care to meet our population’s growing healthcare needs. With a strong community focus, Sengkang Health envisions building an ecosystem of healthy living for the benefit of residents in northeast Singapore.

OTHER ARTICLES

Cell Out? Lysate-Based Expression an Option for Personalized Meds

Article | February 18, 2020

Cell-free expression (CFE) is the practice of making a protein without using a living cell. In contrast with cell line-based methods, production is achieved using a fluid containing biological components extracted from a cell, i.e., a lysate. CFE offers potential advantages for biopharma according to Philip Probert, PhD, a senior scientist at the Centre for Process Innovation in the U.K.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | February 18, 2020

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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2 Small-Cap Biotech Stocks You Haven't Heard of, But Should Know About

Article | February 18, 2020

With everything that's going on with the COVID-19 pandemic, many healthcare companies have grabbed plenty of spotlight during these challenging times. At the same time, a number of otherwise promising businesses have slipped under the radar. That's especially true for small-cap biotech stocks that aren't actively involved in developing tests, vaccines or treatments for COVID-19. Vaccine developers, protective equipment producers, and healthcare service providers are all attracting plenty of attention during this pandemic, but there are just as many promising biotech stocks that aren't involved in these areas. Here are two such companies that you might have missed, but they deserve a spot on your watch list.

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Defense biotech research looks to eliminate bacteria causing traveler’s diarrhea, reduce jet lag duration

Article | February 18, 2020

World traveler‘s will rejoice at the idea of a seemingly magical device that would guarantee they never suffer from the all-too-familiar stomach issues that come from traveling internationally while reducing jet lag at the same time. But it’s not just privileged globetrotters that would benefit from a device that eliminates the bacteria associated with the so-called Montezuma’s Revenge. In 2016, more than 230,000 children around the world died from some of the same types of bacteria as those that cause traveler’s diarrhea, and the bacteria mainly come from unsafe “drinking water, poor sanitation and malnutrition,” according to Oxford University’s Our World In Data portal. On Monday, DARPA announced it was researching an “implantable or ingestible bioelectronic carrier” that would eliminate the five major bacteria associated with traveler’s diarrhea.

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Spotlight

Sengkang Health

Sengkang Health forms a vital part of Singapore’s master plan in providing innovative, quality and accessible healthcare to our vibrant island nation of over five million people. Nestled in the northeast heartland, it will offer cutting-edge general hospital competencies with community-based care. As a member of SingHealth, Singapore’s largest academic healthcare cluster, Sengkang General and Community Hospitals will augment SingHealth’s infrastructure in delivering a full spectrum of care to meet our population’s growing healthcare needs. With a strong community focus, Sengkang Health envisions building an ecosystem of healthy living for the benefit of residents in northeast Singapore.

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