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Webinars

Biotechnology for Aquaculture
BIOTECHNOLOGY FOR AQUACULTURE
Join this 60-minute KnipBio webinar, to learn examples of engineering solutions based on biotechnology that will help the sustainable expansion of this field. Aquaculture, or the farming of fish, shrimp and seaweeds, is expected to continue its dramatic growth in the coming decades. One of the centr...

Efficient tools to enable drug target and biomarker discovery
EFFICIENT TOOLS TO ENABLE DRUG TARGET AND BIOMARKER DISCOVERY
Large-scale sequencing of human tumors has uncovered a vast array of genomic alterations. Genetically engineered mouse models recapitulate many features of human cancer and have been instrumental in assigning biological meaning to specific cancer-associated alterations.

USRM Successfully Launches Stem Cell
USRM SUCCESSFULLY LAUNCHES STEM CELL
Dr. Kristin Comella, Chief Science Officer of U.S. Stem Cell, Inc. a leader in the development of proprietary, physician-based stem cell therapies and novel regenerative medicine solutions, today announced the successful launch of an open, livestream webinar series designed to inform and educate the...

Turn on Your Bio-Engine – Increasing the Profitability of Your Biogas Process
TURN ON YOUR BIO-ENGINE – INCREASING THE PROFITABILITY OF YOUR BIOGAS PROCESS
Learn new methods to optimize the process between anaerobic digestion and the combined heat and power engine. Vaisala’s Product Manager Antti Heikkilä explains in detail the crucial measurement points related to humidity, methane, and carbon dioxide, and demonstrates how biogas production...

Accelerated and AI-Based Genomic Workflows On-Prem and in the Cloud
ACCELERATED AND AI-BASED GENOMIC WORKFLOWS ON-PREM AND IN THE CLOUD
Parabricks has accelerated the secondary analysis of sequencing data to analyze a 30X whole genome in minutes instead of days. Gain an in-depth understanding of how GPUs accelerate industry-standard algorithms used in BWA-Mem, GATK4 and deep learning technologies used in variant calling such as Deep...

Exploring the genetic landscape of solid tumors using whole-genome copy number analysis
EXPLORING THE GENETIC LANDSCAPE OF SOLID TUMORS USING WHOLE-GENOME COPY NUMBER ANALYSIS
Approximately 80% of all cancers are known to be affected by both somatic mutations and copy number changes. Furthermore, recent publications have shown that in certain types of cancers, copy number variations (CNVs) play a more important role than somatic mutations.

Selecting the right tools to build your pluripotent stem cell based disease models
SELECTING THE RIGHT TOOLS TO BUILD YOUR PLURIPOTENT STEM CELL BASED DISEASE MODELS
Human induced pluripotent stem cells (hiPSCs) have been globally recognized as a multipurpose research tool for modeling human disease and biology, screening and developing potential therapeutic drugs, and implementing cell and gene therapies. The ability to differentiate human iPSCs into any cell t...

Bioanalytical Methods Validation
BIOANALYTICAL METHODS VALIDATION
This webinar will review target areas addressed by FDA and EMA current guidance documents and ICH requirements. Current interpretation of guidance documents including failed runs, single stocks for standards and controls. Will address requirements for LC-MS, ligand binding and suggest requirements f...

Can CE-MS Be Used for Antibody Quantitation in Biological Samples?
CAN CE-MS BE USED FOR ANTIBODY QUANTITATION IN BIOLOGICAL SAMPLES?
You’re invited to attend an on-demand webinar to learn how a CE-MS method has been developed to quantitate a reduced monoclonal antibody in biological samples.

Integration of Technology, Process and Quality Control: Protecting Complete Sample Chain of Custody
INTEGRATION OF TECHNOLOGY, PROCESS AND QUALITY CONTROL: PROTECTING COMPLETE SAMPLE CHAIN OF CUSTODY
Implementation of biobanking best practices and analytical platform standardization are two important components for any data generation associated with state of the art biobanks that support precision medicine applications. Sample collection, pre analytical variables, controlled environment storage...

Genetics & Genomics 2019
GENETICS & GENOMICS 2019
Upgrading the CRISPR Toolbox - New Strategies Sharpen the CRISPR-Cas9 Scissors Utilizing Visualization and Chromatic Accessibility

The Immunotherapy Revolution: Towards Future Cancer Treatments
THE IMMUNOTHERAPY REVOLUTION: TOWARDS FUTURE CANCER TREATMENTS
The discovery and development of immune checkpoint inhibitors has revolutionized the treatment of certain cancers, with the 2018 Nobel Prize in medicine/physiology recognizing these therapies as a "landmark in our fight against cancer." Yet, despite these advances, putative biomarker ident...

Using miRNA and Gene Expression Profiling for Biomarker Discovery
USING MIRNA AND GENE EXPRESSION PROFILING FOR BIOMARKER DISCOVERY
Many phenotypes and pathologies arise due to dysregulation of gene expression.  Tracking mRNA levels and the means by which they are regulated helps to understand underlying mechanisms.  For example, alterations in miRNA expression are associated with many human cancers. This has led many ...

Simultaneous Proteomics and Transcriptomics TotalSeq™ and The Future of Single Cell Analysis
SIMULTANEOUS PROTEOMICS AND TRANSCRIPTOMICS TOTALSEQ™ AND THE FUTURE OF SINGLE CELL ANALYSIS
The last few years have seen the scale of single cell RNA-seq experiments increase exponentially, greatly enhancing our understanding of cell biology in development and disease. It is now feasible for researchers to characterize thousands of single cells in one experiment. However, important hallmar...

Capturing Signaling Patterns through Global Phosphorylation Profiling and Intracellular Flow Cytometry
CAPTURING SIGNALING PATTERNS THROUGH GLOBAL PHOSPHORYLATION PROFILING AND INTRACELLULAR FLOW CYTOMETRY
Signals are given in contexts such as mate selection by females, which subjects the advertising males' signals to selective pressure. Signals thus evolve because they modify the behaviour of the receiver to benefit the signaller. Signals may be honest, conveying information which usefully increa...

Genetic Testing: When should you consider testing beyond BRCA?
GENETIC TESTING: WHEN SHOULD YOU CONSIDER TESTING BEYOND BRCA?
Ms. Matloff describes which patients are candidates for genetic testing, summarizes the types of hereditary cancer testing (gene vs panel) available for patient management and discusses the key personal and family history findings that determine which test is best for a particular patient.

Helper Plasmids for Viral Vector Production
HELPER PLASMIDS FOR VIRAL VECTOR PRODUCTION
Success in gene and cell therapy has increased demand for plasmid DNA used to produce viral vectors, both in quantities for commercial products as well as the breadth of different vectors for the expanding number of programs in development.

Challenges in Translating iPSC Technology
CHALLENGES IN TRANSLATING IPSC TECHNOLOGY
Dr. James Wells moderates a panel discussion on the biggest challenges in translating organoid-based cell therapies and the steps needed to bring these technologies to market in an efficient and patient-first manner.

Investing in Biotechnology Startups – Case of Anti-inflammatory Treatments
INVESTING IN BIOTECHNOLOGY STARTUPS – CASE OF ANTI-INFLAMMATORY TREATMENTS
The Webinar will focus on how health sciences are becoming more democratized and decentralized, hacking biotechnology investments is getting more accessible, obvious, and transparent. Investing in biotech is no longer reserved for specialized VCs and funds with deep pockets. This one hour webinar wi...

Assessing Immunotherapy Toxicity in NHPs
ASSESSING IMMUNOTHERAPY TOXICITY IN NHPS
New immunotherapies are generating unprecedented clinical response. However, immune activation by I/O agents can also cause notable and potentially fatal clinical toxicity, such as cytokine storms, which is not observed in preclinical studies. Immuno-safety has therefore become a major clinical conc...

Overcoming Challenges in NAFLD/NASH Preclinical Modeling
OVERCOMING CHALLENGES IN NAFLD/NASH PRECLINICAL MODELING
While the race for the first clinical NASH approval intensifies, preclinical research continues to be limited by multiple factors. There is no ideal preclinical NASH model, naturally recapitulating both the long term metabolic and liver fibrosis components of NASH, and existing clinical tests are no...

Enabling the next level of pluripotent stem-cell based therapies, from bench to commercialization
ENABLING THE NEXT LEVEL OF PLURIPOTENT STEM-CELL BASED THERAPIES, FROM BENCH TO COMMERCIALIZATION
Stem cell-based therapies require innovative solutions to close the gaps existing between research and commercialization. Allogeneic cell therapy indications that target large patient populations will necessitate the use of flexible cell production platforms to meet the increasing demand of cell qua...

Implementation of Biopreservation Best Practices to address a critical component of cell and gene therapy manufacturing
IMPLEMENTATION OF BIOPRESERVATION BEST PRACTICES TO ADDRESS A CRITICAL COMPONENT OF CELL AND GENE THERAPY MANUFACTURING
There is more to Biopreservation than storage on ice or freezing at a rate of -1°C/min. To comprehend the rationale behind Biopreservation Best Practices, a basic understanding of cellular response to cold and freezing is essential. This presentation will identify the critical process parameters...

Emerging GMP-Grade Raw Materials & Technologies for Cell Therapy
EMERGING GMP-GRADE RAW MATERIALS & TECHNOLOGIES FOR CELL THERAPY
In this insightful webinar, our panel of industry leading experts explore how to plan for the successful development of new cell therapies using emerging raw materials and technologies.

Mind the Yap! Single-Cell Transcriptomes Reveal Drivers of Intestinal Regeneration
MIND THE YAP! SINGLE-CELL TRANSCRIPTOMES REVEAL DRIVERS OF INTESTINAL REGENERATION
Controlling organ growth size is an evolutionarily conserved process regulated by molecules within the Hippo pathway—a unique signaling module that regulates cell-specific transcription in response to a wide range of intra- and extracellular cues. In addition to its conventional role in restri...

Live-Cell Analysis Virtual event
LIVE-CELL ANALYSIS VIRTUAL EVENT
This event offers an overview of how live-cell analysis enables real-time analysis for the full workflow of the cells. Start at the beginning and learn more about the cell health, growth and morphology of your cells in culture.  From there, gain a better understanding of the efficiency of trans...

CANCER ON A CHIP
CANCER ON A CHIP
At present cancer research focuses on three major areas viz. cancer diagnostics, drugs development, and next-generation therapies. About 90% of the in-vitro research rely on traditional two-dimensional (2D) monolayer cell culture systems. 2D cell culture systems fail to accurately recapitulate the s...

Automated, large-scale and GMP-compliant cell manufacturing
AUTOMATED, LARGE-SCALE AND GMP-COMPLIANT CELL MANUFACTURING
Regenerative medicine has become a key focus worldwide and the number of stem cell therapy trials are rapidly increasing every year. Yet, large-scale and GMP-compliant stem cell manufacturing is still a major hurdle for clinical applications across the globe. In this webinar, we will show you how to...

3D Modeling of Skeletal Muscle for In Vitro Functional Assaying
3D MODELING OF SKELETAL MUSCLE FOR IN VITRO FUNCTIONAL ASSAYING
In this webinar, Dr. Penney Gilbert from the University of Toronto explains how her group has uncovered regulators of muscle hypertrophy by inducing exercise-like rounds of contractions in their 3D skeletal muscle models.

Neuroimmune Interactions in Development, Health, and Disease
NEUROIMMUNE INTERACTIONS IN DEVELOPMENT, HEALTH, AND DISEASE
It is increasingly appreciated that crosstalk at the nexus of the nervous and immune systems mediates a delicate balance between dysregulation and homeostasis across many important biological processes. In this Cell Press webinar, three speakers will explore emerging developments in our understandin...

Single-Cell Analysis for Understanding Identity and Diversity
SINGLE-CELL ANALYSIS FOR UNDERSTANDING IDENTITY AND DIVERSITY
The study of single cells has revolutionized our understanding of cell identity, diversity, development, and function, bridging basic science and precision medicine and ushering in technological advances that will revolutionize both. In this Cell Press Webinar,Smita Krishnaswamy (Yale University), J...

The Importance of Procalcitonin for Antimicrobial Stewardship in Patients with Lower Respiratory Tract Infections in the Emergency Department
THE IMPORTANCE OF PROCALCITONIN FOR ANTIMICROBIAL STEWARDSHIP IN PATIENTS WITH LOWER RESPIRATORY TRACT INFECTIONS IN THE EMERGENCY DEPARTMENT
This webinar will explore how using  a procalcitonin (PCT) driven protocol in the Emergency Room can aid clinicians in deciding about hospital admission versus treatment in the home setting.  We will look at the existing data using procalcitonin in patients with presumed Lower Respiratory ...

Factors to Consider During Adaptation of a Manual Cell Line Development Workflow to Automation
FACTORS TO CONSIDER DURING ADAPTATION OF A MANUAL CELL LINE DEVELOPMENT WORKFLOW TO AUTOMATION
Mammalian cell line generation is a rate-limiting step in early CMC development and there is a constant desire to increase throughput.  The implementation of automation is one way to increase throughput. This webinar will address some factors to consider during the process of automating a manua...

FDA FSMA Preventive Controls: Cross Contact and Contact Contamination
FDA FSMA PREVENTIVE CONTROLS: CROSS CONTACT AND CONTACT CONTAMINATION
Biological, chemical and physical contaminants continue to play a significant role in causing human illness and death. While most food supply companies are becoming slowly aware of the breadth of system responsibilities they must assume in terms of preventing food safety problems, many are ineffecti...

Assessing Immunotherapy Toxicity in NHPs
ASSESSING IMMUNOTHERAPY TOXICITY IN NHPS
New immunotherapies are generating unprecedented clinical response. However, immune activation by I/O agents can also cause notable and potentially fatal clinical toxicity, such as cytokine storms, which is not observed in preclinical studies. Immuno-safety has therefore become a major clinical conc...

Connective Tissue-Specific Stem and Progenitor Cells: from Biology to the Clinic, Challenges and Advances
CONNECTIVE TISSUE-SPECIFIC STEM AND PROGENITOR CELLS: FROM BIOLOGY TO THE CLINIC, CHALLENGES AND ADVANCES
Connective tissue-specific stem and progenitor cells (also known asa mesenchymal stormal/stem cells or MSCs) have been the subject of clinical testing for various conditions, but the outcomes of advanced clinical trials have fallen short of expectations raised by encouraging pre-clinical animal data...

No Further Questions: Preparing for Expert Witness Testimony on Probabilistic Genotyping
NO FURTHER QUESTIONS: PREPARING FOR EXPERT WITNESS TESTIMONY ON PROBABILISTIC GENOTYPING
With approximately half the forensic laboratories in the United States either using a probabilistic genotyping system or in some stage of implementation, cases processed using this method are now making their way through the court systems.

How to reach high plasma protein concentration with single-pass TFF
HOW TO REACH HIGH PLASMA PROTEIN CONCENTRATION WITH SINGLE-PASS TFF
Single-Pass Tangential Flow Filtration (SPTFF) is a technology that requires only one pass through the filter assembly to achieve the desired concentration with no recirculation of product.

Facility Intensification and Cost Reduction using an Integrated Buffer Delivery Platform
FACILITY INTENSIFICATION AND COST REDUCTION USING AN INTEGRATED BUFFER DELIVERY PLATFORM
Outsourcing or implementing a streamlined buffer preparation and management systems allows biomanufacturers to considerably reduce floor usage, labor and costs. In this webinar, we will explore the benefits of an Integrated Buffer Delivery Platform.

Single-Cell DNA Sequencing in MBL and CLL
SINGLE-CELL DNA SEQUENCING IN MBL AND CLL
Our mission is to help researchers and clinicians unlock single-cell biology to enable the discovery, development, and delivery of precision medicine.a

Tapestri: The Precision Genomics Platform
TAPESTRI: THE PRECISION GENOMICS PLATFORM
Our mission is to help researchers and clinicians unlock single-cell biology to enable the discovery, development, and delivery of precision medicine.

VIRAL SAFETY BY DESIGN FOR CELL AND GENE THERAPY PRODUCTS
VIRAL SAFETY BY DESIGN FOR CELL AND GENE THERAPY PRODUCTS
Together with product efficacy, product safety is an essential characteristic of any medicinal product including cell and gene therapy (C>) biologics. Adventitious agents (viruses, bacteria, mycoplasma, prions, etc) pose constant risk to these biologics, and, as such they may impact directly prod...

The Next Generation in Light Scattering for the Characterization of Macromolecules and Nanoparticles
THE NEXT GENERATION IN LIGHT SCATTERING FOR THE CHARACTERIZATION OF MACROMOLECULES AND NANOPARTICLES
You will be hearing from a variety of Scientists from Wyatt Technology who will help explain some of the key advancements and improvements made in light scattering that we believe will provide future customers with state-of-the-art capabilities and unique benefits.

Employing Innovative Platform Manufacturing and Biosafety Testing for your Gene Therapy Product to Reduce Time to Market
EMPLOYING INNOVATIVE PLATFORM MANUFACTURING AND BIOSAFETY TESTING FOR YOUR GENE THERAPY PRODUCT TO REDUCE TIME TO MARKET
As gene therapies and gene-modified cell therapies show increasing promise, the need for innovative and proficient viral vector manufacturing continues to grow. Concurrently, increased regulatory guidance governing the manufacturing and testing of viral vectors adds complexity and increases the time...

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
GENOME-WIDE CRISPR SCREENS IN PRIMARY HUMAN T CELLS REVEAL KEY REGULATORS OF IMMUNE FUNCTION
Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioritize novel targets for drug development and improve the design of genetically reprogrammed cell-based therapies.

Initial Evaluation of the ClearLLab  10C System in the Immunophenotyping  of Leukemia and Lymphoma
INITIAL EVALUATION OF THE CLEARLLAB 10C SYSTEM IN THE IMMUNOPHENOTYPING OF LEUKEMIA AND LYMPHOMA
Mike Keeney from Lawson Health Research Institute, Ontario, will present "Initial evaluation of the ClearLLab  10C System in the Immunophenotyping of Leukemia and Non Hodgkin Lymphoma". The presentation will introduce the new ClearLLab 10 Color System and the ClearLLab Control Cells, ...

High-Dimensional Human Immune Profiling Simplified
HIGH-DIMENSIONAL HUMAN IMMUNE PROFILING SIMPLIFIED
Immune profiling of PBMC and peripheral whole blood is an essential method for quantifying changes in immune cell populations in autoimmune disease, chronic inflammation, infectious disease and cancer.

Measuring Multivalent Interactions: Uncovering the Secrets of Virus Binding Strategies
MEASURING MULTIVALENT INTERACTIONS: UNCOVERING THE SECRETS OF VIRUS BINDING STRATEGIES
Influenza A virus (IAV) utilizes a multivalent binding strategy to the host cell, binding its trimeric spike protein hemagglutinin (HA) to sialic acid present on the cellular membrane.

The new wave in bio-based materials: maximum value from lignin with industry-specific fractions
THE NEW WAVE IN BIO-BASED MATERIALS: MAXIMUM VALUE FROM LIGNIN WITH INDUSTRY-SPECIFIC FRACTIONS
The era of affordable sugars, renewable biochemical and bio-based materials from lignocellulosic feedstock are here. Enabling a paradigm shift from petroleum and change over to renewable biomass, the new fractionation technologies of lignin allow the entire biomass to be utilized. Lignocellulosic bi...

Recent Advances and the Future of Antibody Engineering
RECENT ADVANCES AND THE FUTURE OF ANTIBODY ENGINEERING
The therapeutic antibody market has reached a fever pitch of enthusiasm, in no small part due to successes of recent drug approvals for a host of disorders such as psoriasis, multiple sclerosis, C. difficile infections, and cancer.

Simplifying ChIP from Primary Cells and Clinical Samples for Epigenetic Applications
SIMPLIFYING CHIP FROM PRIMARY CELLS AND CLINICAL SAMPLES FOR EPIGENETIC APPLICATIONS
Mapping the epigenetic and transcription factor landscape is essential for understanding gene regulatory mechanisms and holds huge potential for identification of biomarkers and targets for epigenetic therapy.

Is Non-Responder the best Imputation Methodi in Equivalence Trials?
IS NON-RESPONDER THE BEST IMPUTATION METHODI IN EQUIVALENCE TRIALS?
In this webinar, our Senior Statistician Laura Cope will illustrate how to assess Non-Responder Imputations in Equivalence Trials.

Gene Therapy for Rare Diseases
GENE THERAPY FOR RARE DISEASES
There are approximately 7,000 distinct rare diseases affecting 350 million people worldwide, approximately 80 percent of which are caused by faulty genes.

White Biotech
WHITE BIOTECH
Japanese companies have access to advanced technologies, and government programs within public-private partnerships support rapid and broad advances. However, Japan is constantly looking out to introduce fresh science and technology, and ready to partner with foreign technology providers if this is ...

Undergraduate Neuroscience Pedagogy: Perspectives From Different Institutions
UNDERGRADUATE NEUROSCIENCE PEDAGOGY: PERSPECTIVES FROM DIFFERENT INSTITUTIONS
In this webinar for SfN and Faculty for Undergraduate Neuroscience (FUN) members, hear from undergraduate faculty who will share their best practices in undergraduate pedagogy implemented at a variety of institutions: liberal arts colleges, a mid-sized university, and a large research institution.

Gene Therapy to Address Unmet Needs in Neurology
GENE THERAPY TO ADDRESS UNMET NEEDS IN NEUROLOGY
Advances in gene therapy have propelled the field into the clinical realm, and new medical treatment options are beginning to offer help in neurological diseases long thought to be incurable.

Human Genome Editing Webinar with NAS/NAM
HUMAN GENOME EDITING WEBINAR WITH NAS/NAM
DNA defines who we are. And like anything else, sometimes there are mistakes – mutations in genes that can cause life-lasting conditions. But what if broken genes could be repaired? How many patients could we help in the years ahead? This is the promise and possibility of genome editing.

Cancer Gene Expression Targets Validated Using Novel Histopathology Tools
CANCER GENE EXPRESSION TARGETS VALIDATED USING NOVEL HISTOPATHOLOGY TOOLS
When assessing a potential biological therapeutic candidate, several histopathological technologies are typically employed. This ensures the target expression is validated in both normal and diseased tissues before proceeding with pre-clinical studies. Protein B is a transmembrane glycoprotein that ...

Association Rate Constant: The Unsung Hero of Drug Discovery Kinetics
ASSOCIATION RATE CONSTANT: THE UNSUNG HERO OF DRUG DISCOVERY KINETICS
While the importance of ligand-receptor binding kinetics on drug action is becoming well established, focus to date has been almost entirely on the role of the dissociation constant on drug efficacy and duration of action. The association rate constant, in contrast, has been largely overlooked, with...

De-Risky Business: Assessing Biotherapeutic Off-Target and On-Target Liabilities
DE-RISKY BUSINESS: ASSESSING BIOTHERAPEUTIC OFF-TARGET AND ON-TARGET LIABILITIES
Toxicity failures caused by off-target or unintended on-target liabilities are a leading cause of attrition in clinical and preclinical programs. Given the effort, cost, and technical limitations of traditional biopharmaceutical de-risking strategies, there is a need for a robust and scalable approa...

Why are Lipid Formulations Commonly Used to Enhance Bioavailability?
WHY ARE LIPID FORMULATIONS COMMONLY USED TO ENHANCE BIOAVAILABILITY?
Enabling formulations becomes more and more necessary to obtain adequate exposure of APIs during (pre)-clinical research. Currently, most registered formulations to improve bioavailability are based on lipidic systems, which make use of intrinsic digestion processes within the GI tract, facilitating...

Biology by Design: Applying Gigabases of DNA to Bioengineering
BIOLOGY BY DESIGN: APPLYING GIGABASES OF DNA TO BIOENGINEERING
For more than 15 years, the costs of DNA sequencing and synthesis have been improving faster than Moore’s Law. The impacts of the improvements made to DNA sequencing are well known: whereas the original Human Genome Project cost several billion dollars, a human genome can be sequenced today fo...

De-Risky Business: Assessing Biotherapeutic Off-Target and On-Target Liabilities
DE-RISKY BUSINESS: ASSESSING BIOTHERAPEUTIC OFF-TARGET AND ON-TARGET LIABILITIES
De-Risky Business: Assessing Biotherapeutic Off-Target and On-Target Liabilities
Toxicity failures caused by off-target or unintended on-target liabilities are a leading cause of attrition in clinical and preclinical programs. Given the effort, cost, and technical limitations of traditional b...

Advanced ODT Technologies for Drug Development in Japan and the US
ADVANCED ODT TECHNOLOGIES FOR DRUG DEVELOPMENT IN JAPAN AND THE US
CMIC Group, the first and largest CRO in Japan with extended services in drug development and GMP manufacturing in the US, Japan and Asia, held a webinar Advanced ODT Technologies for Drug Development in Japan and the US on April 11, 2019.Since its introduction in the 1980s, the market of orally dis...

Aprecia and CMIC, a Leading CDMO in Japan, have established an agreement to bring 3DP pharmaceutical products to Japan
APRECIA AND CMIC, A LEADING CDMO IN JAPAN, HAVE ESTABLISHED AN AGREEMENT TO BRING 3DP PHARMACEUTICAL PRODUCTS TO JAPAN
Privately held Aprecia Pharmaceuticals, LLC (Aprecia) and CMIC CMO Co., LTD (CMIC CMO) today announced that both companies will collaborate to develop business opportunities in Japan for Aprecias ZipDoseTechnology. CMIC CMOs services will include identifying prospects in Japan, generating awareness ...

Exploring MALDI-TOF mass spec for mycobacteria
EXPLORING MALDI-TOF MASS SPEC FOR MYCOBACTERIA
The Food and Drug Administration in 2017 approved MALDI-TOF mass spectrometry for the identification of mycobacteria. What is the protocol? How is workflow affected? Are there cost savings and turnaround time improvements? Omai Garner, PhD, D(ABMM), answered these and other questions and shared his ...

The Evolving Role of BRCA Testing in Ovarian Cancer
THE EVOLVING ROLE OF BRCA TESTING IN OVARIAN CANCER
Webinar presenters Dana Chase, MD, FACOG,Assistant Professor, Division of Gynecologic Oncology University of Arizona College of Medicine, Phoenix, AZ, Creighton University School of Medicine at St. Joseph’s Hospital, Phoenix, AZ, Gynecologic Oncologist, Arizona Oncology, and John Longshore, Ph...

IGHV gene mutation at heart of CLL treatment
IGHV GENE MUTATION AT HEART OF CLL TREATMENT
IGHV mutation analysis should be top of mind when acquiring prognostic and potentially therapeutic information in chronic lymphocytic leukemia, said Curtis A. Hanson, MD, in a CAP TODAY webinar made possible by a special educational grant from Diaceutics. Dr. Hanson, professor of laboratory medicine...

How to interpret clinical trial results like a pro
HOW TO INTERPRET CLINICAL TRIAL RESULTS LIKE A PRO
Clinical trial data can be remarkably (and unnecessarily) difficult to read. Companies spin, short-sellers hawk, and everyone else is left swimming through the muck. But there is an art to reading scientific results — and you can learn it.

The future of clinical trials
THE FUTURE OF CLINICAL TRIALS
The drug industry, with encouragement from the Food and Drug Administration, is advancing efforts to modernize clinical trials, streamlining the process of figuring out whether a treatment actually works.

The race to deliver CRISPR
THE RACE TO DELIVER CRISPR
The gene-edited babies controversy got all the headlines, but there’s a lot more going on with the technology known as CRISPR these days.

Clinically-Relevant Transporters, Clinical Probes and DDI Evaluation
CLINICALLY-RELEVANT TRANSPORTERS, CLINICAL PROBES AND DDI EVALUATION
This presentation will summarize the state-of-the-art in transporters in drug development based on four recent ITC3 whitepapers (Clin Pharmacol Ther 104, October 2018).  Practical overview of emerging transporters of clinical relevance will be provided (e.g., OCT1, OATP2B1, etc.).  Best pr...

BIO 2018 Partnering Webinar: How to Get the Most ROI in Boston
BIO 2018 PARTNERING WEBINAR: HOW TO GET THE MOST ROI IN BOSTON
BIO One-on-One Partnering™ is the most efficient way to do business in the biotech and pharma industry without traveling all over the world. Our system makes it easy to search for and identify potential partners and request meetings with prospective biotech investors and senior business develo...

BIO 2018 Advanced Partnering Webinar: Partnering Power Tools
BIO 2018 ADVANCED PARTNERING WEBINAR: PARTNERING POWER TOOLS
This webinar is designed for BIO 2018 attendees who are familiar with the BIO One-on-One Partnering™ system and want to use the platform more effectively. Join this advanced partnering webinar—led by BIO’s Director of Partnering—to learn about new system enhancements, commonl...

INTRODUCING CHROMASSETTE®, A MODULAR CHROMATOGRAPHY PLATFORM ENABLING NEXT-GENERATION BIOPROCESS PURIFICATION.
INTRODUCING CHROMASSETTE®, A MODULAR CHROMATOGRAPHY PLATFORM ENABLING NEXT-GENERATION BIOPROCESS PURIFICATION.
We will introduce Chromassette® and an application example of an integrated rapid single pass process from harvest to purified bulk, a concept demonstrated by AbbVie. Chromassette is a stackable, single-use and pre-packed chromatography cassette with a supported bed, addressing the current key c...

Viruses in Soils
VIRUSES IN SOILS
Viruses outnumber bacteria in soil by as much as 1000:1. However, there are few studies which examine the ways viral communities impact the soil microbiome, chemical cycles, and plants. Recent advances in viral ecology make it a discussion of soil viral ecology especially timely.

The Evolution of Diverse, Ubiquitous CRESS DNA Viruses
THE EVOLUTION OF DIVERSE, UBIQUITOUS CRESS DNA VIRUSES
Circular, Rep-encoding single-stranded (CRESS) DNA viruses were once thought to be a rare kind of viral genomic architecture.  While some significant agricultural diseases were caused by circoviruses and geminiviruses, they are not typically human pathogens, and it was only when metagenomic met...

The Hurricane Microbiome Project
THE HURRICANE MICROBIOME PROJECT
  The Alkek Center for Metagenomics and Microbiome Research (CMMR) at Baylor College of Medicine is pursuing numerous research and development efforts in the study of how the microbiome impacts human disease and how this knowledge can be translated into novel therapeutics and diagnostics. ...

Evolution of Hematopoietic Stem Cell Gene Therapy
EVOLUTION OF HEMATOPOIETIC STEM CELL GENE THERAPY
In the nearly two decades since the first successful use of gene therapy, transplantation of gene modified autologous hematopoietic stem cells (HSCs) is emerging as a viable treatment for a number of genetic blood cell and metabolic diseases and for some may even become standard of care.

High-Throughput Single-Molecule Technologies
HIGH-THROUGHPUT SINGLE-MOLECULE TECHNOLOGIES
The past decade has witnessed an emergence of technologies from various disciplines that are providing unprecedented opportunities to formulate and answer new types of biological questions. In particular, single-molecule approaches are revolutionizing biological inquiries by providing previously una...

Cryo-electron Tomography for Cell Biology
CRYO-ELECTRON TOMOGRAPHY FOR CELL BIOLOGY
Cryo-electron tomography can visualize macromolecular structures in situ, inside the cell.  Vitreous frozen cells are first thinned with a focused ion beam and then imaged in three dimensions using a transmission electron microscope.  This transformative method has the power to revolutioni...

Turn on Your Bio-Engine – Increasing the Profitability of Your Biogas Process
TURN ON YOUR BIO-ENGINE – INCREASING THE PROFITABILITY OF YOUR BIOGAS PROCESS
New methods to optimize the process between anaerobic digestion and the combined heat and power engine. Vaisala’s Product Manager Antti Heikkilä explains in detail the crucial measurement points related to humidity, methane, and carbon dioxide, and demonstrates how biogas production can b...

Automation is key to siRNA
AUTOMATION IS KEY TO SIRNA
siRNA, which stands for small interfering Ribonucleic Acid, is a class of double-stranded RNA molecules. It is sometimes known as short interfering RNA or silencing RNA. Before diving into what exactly siRNA is, not to be confused with miRNA, it's important to know the function of RNAs.

Biology by Design: Applying Gigabases of DNA to Bioengineering
BIOLOGY BY DESIGN: APPLYING GIGABASES OF DNA TO BIOENGINEERING
For more than 15 years, the costs of DNA sequencing and synthesis have been improving faster than Moore’s Law. The impacts of the improvements made to DNA sequencing are well known: whereas the original Human Genome Project cost several billion dollars, a human genome can be sequenced today fo...

Can CE-MS be used for Antibody Quantitation in Biological Samples?
CAN CE-MS BE USED FOR ANTIBODY QUANTITATION IN BIOLOGICAL SAMPLES?
Current liquid chromatography-mass spectrometry (LC-MS) methods used to detect monoclonal antibodies (mAbs) in biological samples are focused on targeted tryptic peptide quantitation, which requires that the mAbs undergo tryptic digestion before analysis. The use of digestion complicates the workflo...

Accurate Prediction of On- and Off-Target Cardiotoxicity with Human iPSC-Derived Cardiomyocytes
ACCURATE PREDICTION OF ON- AND OFF-TARGET CARDIOTOXICITY WITH HUMAN IPSC-DERIVED CARDIOMYOCYTES
Latent cardiovascular toxicity issues continue to plague late-stage drug discovery efforts, as well as commercially launched pharmaceutical success. Many current in vitro models lack, or incompletely recapitulate, important aspects of human cardiac biology, thus allowing certain toxicities to escape...

Pluripotent stem cells: How to raise the quality of your PSC culture
PLURIPOTENT STEM CELLS: HOW TO RAISE THE QUALITY OF YOUR PSC CULTURE
PSCs represent an important tool in a wide range of applications, including basic research, disease modeling, drug discovery, and regenerative medicine. As stem cell cultures are very sensitive and respond to the smallest influence, stable culture conditions are crucial to maintain reliability and r...

Regulatory Strategies for the Analytical Development of New Biological Entities and Biosimilars
REGULATORY STRATEGIES FOR THE ANALYTICAL DEVELOPMENT OF NEW BIOLOGICAL ENTITIES AND BIOSIMILARS
The webinar will focus on the relationship between analytics of biotherapeutic products and the interpretation of data to build and support a solid regulatory Chemistry, Manufacturing and Control (CMC) strategy. The importance of data interpretation is illustrated in the development of biosimilars a...

How a Top-5 Pharma Doubled the Speed of Cell Line Development
HOW A TOP-5 PHARMA DOUBLED THE SPEED OF CELL LINE DEVELOPMENT
Single cell cloning (SCC) is a critical and high value process for an increasing number of applications including cell engineering; stable cell lines for therapeutic mAbs and biosimilars; vector production for gene therapy; and many more. During this webinar, Tom Kelly from Janssen (part of Johnson ...

Ergot Alkaloids: From Witchcraft to Biotechnology
ERGOT ALKALOIDS: FROM WITCHCRAFT TO BIOTECHNOLOGY
Ergots alkaloids are secondary metabolites of certain fungi. Their production occurs in the sclerotia of the Claviceps species on infected cereal plants during cool, wet weather with rye being the main host. It is important to detect these mycotoxins, as ergot alkaloids can remain in stored grains a...

Biotech Showcase: Comparing Informatics Platforms of 2 Biotech Organizations
BIOTECH SHOWCASE: COMPARING INFORMATICS PLATFORMS OF 2 BIOTECH ORGANIZATIONS
Discussion on this webinar was lively and highly informed. Watch the recording below to see the Foghorn Therapeutics collaborative scientific team of David Lahr (Head of Informatics), Joe Marchionna (Research Informatics), and Johannes Voigt (Computational Chemist), together with An2h Discovery CSO ...

Principles of Transporter Drug Interactions with Special Focus on Hepatic and BBB Transporters
PRINCIPLES OF TRANSPORTER DRUG INTERACTIONS WITH SPECIAL FOCUS ON HEPATIC AND BBB TRANSPORTERS
Transporters are involved in clinically significant drug-drug interactions (DDI). Such interactions can occur at multiple sites, including in organs important in drug absorption (e.g. intestine), elimination (e.g. liver and kidneys) and distribution (e.g. brain). Notably, some of these interactions ...

Biotin interference on immunoanalyses
BIOTIN INTERFERENCE ON IMMUNOANALYSES
In this webinar, Marie Piketty recalls that in recent years, several cases of interference caused by Biotin have been reported, concerning doses of thyroid hormones, but also other hormones, and other dosages. Biotin also called Vitamin B7, is a cofactor of several reactions to the carboxylase. Biot...

Biometrics - The future of web and mobile authentication
BIOMETRICS - THE FUTURE OF WEB AND MOBILE AUTHENTICATION
Bio-metrics authentication is fast replacing passwords as the choice of authentication technique on web and mobile applications. This webinar covers various bio-metric options, comparative benefits and emerging trends.

In Situ Bioremediation and In Situ Chemical Reduction for Remediation of 1,2,3-Trichloropropane in Groundwater
IN SITU BIOREMEDIATION AND IN SITU CHEMICAL REDUCTION FOR REMEDIATION OF 1,2,3-TRICHLOROPROPANE IN GROUNDWATER
1,2,3-trichloropropane (TCP) is an emerging groundwater contaminant that is present in widely-used soil fumigants. Individual states have or are in the process of developing regulatory levels for TCP that are as low as 0.0005 micrograms per litre (µg/L). Remedial technologies for TCP that have...

Documenting Biodegradation when the Products are Difficult to Discern
DOCUMENTING BIODEGRADATION WHEN THE PRODUCTS ARE DIFFICULT TO DISCERN
For common groundwater contaminants such as chlorinated ethenes, demonstrating biodegradation activity based on detection of daughter products is straightforward, since the products are readily discernible from background sources.  However, this is not the case for all contaminants.  With ...

Experimental Considerations when Planning Chronic Models of Cardiovascular Disease in Rodents
EXPERIMENTAL CONSIDERATIONS WHEN PLANNING CHRONIC MODELS OF CARDIOVASCULAR DISEASE IN RODENTS
During this educational webinar, Dr. Timothy A. Hacker discusses strategies and experimental design of long-term, chronic cardiovascular research in rodents. Specifically, he reviews the use of implantable telemetry, imaging and complimentary technologies for cardiovascular research, highlighting wh...

Single-Cell Electrophysiology and 2-Photon Imaging in Awake Mice with 2D-Locomotion Tracking
SINGLE-CELL ELECTROPHYSIOLOGY AND 2-PHOTON IMAGING IN AWAKE MICE WITH 2D-LOCOMOTION TRACKING
In this webinar, experts present their research utilizing the Mobile Home Cage, an experimental tool which ensures the stability required for high-precision neurophysiological techniques while allowing awake mice to navigate and explore their environment.

Win More Biologics Development Battles with Early Stability Analysis
WIN MORE BIOLOGICS DEVELOPMENT BATTLES WITH EARLY STABILITY ANALYSIS
Biophysical and chemical properties are critical factors that can dictate success or failure in the development of therapeutic antibodies. These attributes and all the functional characteristics of antibodies depend on amino acid sequence, post-translational modifications, and the solution environme...

The Regulation of Biotechnology Products
THE REGULATION OF BIOTECHNOLOGY PRODUCTS
This webinar will provide an introduction to biotechnology products for regulatory affairs professionals.

ATMPs, Human Tissues and the MDR
ATMPS, HUMAN TISSUES AND THE MDR
This webinar will give you sufficient understanding to classify new products and technologies containing human tissues or cells and to understand the impact of such products in a portfolio.

Clinical pathology selected abstracts
CLINICAL PATHOLOGY SELECTED ABSTRACTS
Prostate cancer is the second most common cancer and the fifth leading cause of cancer-associated mortality among men worldwide. The use of serum prostate-specific antigen (PSA) to screen for prostate cancer is intended to detect the cancer at an early stage to reduce overall and disease-specific mo...

High-parameter immune monitoring panel
HIGH-PARAMETER IMMUNE MONITORING PANEL
Fluidigm introduced its Maxpar Human Immune Monitoring Panel Kit for comprehensive immune cell profiling in cancer and immune-mediated diseases. The immune monitoring kit contains 29 metal-labeled antibodies and reagents designed for deep immune profiling of human peripheral blood mononuclear cells ...

Cancer Gene Expression Targets Validated Using Novel Histopathology Tools
CANCER GENE EXPRESSION TARGETS VALIDATED USING NOVEL HISTOPATHOLOGY TOOLS
When assessing a potential biological therapeutic candidate, several histopathological technologies are typically employed. This ensures the target expression is validated in both normal and diseased tissues before proceeding with pre-clinical studies. Protein B is a transmembrane glycoprotein that ...

Fibro-Inflammatory Disease Sees Relief in IL-11 mAb Development
FIBRO-INFLAMMATORY DISEASE SEES RELIEF IN IL-11 MAB DEVELOPMENT
Biologic drugs have dominated the biopharmaceutical market in recent years and show no signs of slowing. While there is no shortage of therapeutic targets for drug developers designing monoclonal antibodies (mAB), validating those targets for clinical efficacy in various disease models is growing in...

Cancer Research & Oncology 2017
CANCER RESEARCH & ONCOLOGY 2017
LabRoots invites research professionals, scientists, and clinicians to this premier online conference, making it easier and more cost-effective to learn about recent advances in cancer research. The virtual conference is free to attendees, encouraging worldwide collaboration and connections between ...

Cell Biology 2018
CELL BIOLOGY 2018
This field spans through most scientific disciplines, studying cell imaging, stem cells, cell physiology and structure, cell signaling, cell culture, and translational biology, and encompassing other scientific fields such as cancer biology, neuroscience, genetics, bioengineering and so much more. T...

Optimizing soluble protein expression: codon optimization, RBS design, and expression vector design
OPTIMIZING SOLUBLE PROTEIN EXPRESSION: CODON OPTIMIZATION, RBS DESIGN, AND EXPRESSION VECTOR DESIGN
Do you wish there were an easy way to optimize protein expression? This webinar will introduce you to three powerful strategies that can make your research more efficient: codon optimization, ribosome binding site design, and expression vector selection. We will describe the principles underlying th...

Super-Resolution Approaches for Capturing Cellular Dynamics
SUPER-RESOLUTION APPROACHES FOR CAPTURING CELLULAR DYNAMICS
Super-resolution microscopy techniques have facilitated imaging some of the smallest cellular structures with amazing detail and have led to key discoveries in molecular and cell biology, immunology, and neurobiology. Now, there is an increasing need to bring this level of detail to rapidly-occurrin...

Probing Epigenomic Heterogeneity in Single Cells
PROBING EPIGENOMIC HETEROGENEITY IN SINGLE CELLS
The advent of single cell approaches for studying chromatin accessibility, including single-cell ATAC-seq and single-cell RNA-seq, has enabled characterization of epigenomes at single cell resolution. These studies contribute to a systems-level understanding of epigenomic variation at the single-cel...

Micro-Flow Imaging as a Tool for Biopharmaceutical Particle Analysis
MICRO-FLOW IMAGING AS A TOOL FOR BIOPHARMACEUTICAL PARTICLE ANALYSIS
The size of poly(lactic-co-glycolic) acid (PLGA) microparticles is of critical importance for polymer degradation and drug release rates. Current methods for the characterization of PLGA microparticle size provide only limited or no quantitative information or may overestimate size due to the presen...

Cell Line Solutions for Assay Development and Bioproduction
CELL LINE SOLUTIONS FOR ASSAY DEVELOPMENT AND BIOPRODUCTION
Cultivating and managing productive cell cultures is of critical importance to the biopharmaceutical industry. Recent discoveries using stem cells, advances in cell based therapeutics, and the rapid expansion of the biosimilar market has investigators searching for technologies that will improve the...

PREPARE YOUR ENTERPRISE CLOUD STRATEGY FOR 2019: 7 THINGS TO THINK ABOUT NOW
PREPARE YOUR ENTERPRISE CLOUD STRATEGY FOR 2019: 7 THINGS TO THINK ABOUT NOW
Cloud adoption just keeps on growing and now is the time to take control. Your enterprise cloud strategy for 2019 needs to address the broad impact of cloud use in your company. Your strategy should also cover implications for your technical processes, as well as supporting areas including finance, ...

AWS Partner Webinars On Demand
AWS PARTNER WEBINARS ON DEMAND
Attend AWS Partner Webinars on demand to learn about topics ranging from Migration and Security to IoT and more. Each webinar includes live demonstrations, customer use cases, and Q&A sessions hosted by AWS experts and select AWS Partner Network (APN) Competency Partners.

Bioprocess Automation for PAT with BioProfile FLEX2 plus Seg-Flow
BIOPROCESS AUTOMATION FOR PAT WITH BIOPROFILE FLEX2 PLUS SEG-FLOW
Nova Biomedical develops and manufactures automated chemistry and cell culture analyzers to rapidly test key nutrients, metabolites, gases, osmolality, and cell density for mammalian cell culture and fermentation media.

The Regulation of Biotechnology Products
THE REGULATION OF BIOTECHNOLOGY PRODUCTS
This webinar will provide an introduction to biotechnology products for regulatory affairs professionals.

[Recorded Webinar] RNA Based Therapeutics and Vaccines: Bioprocessing Technology Trends
[RECORDED WEBINAR] RNA BASED THERAPEUTICS AND VACCINES: BIOPROCESSING TECHNOLOGY TRENDS
According to market research, DNA and RNA therapeutics are growing at 12% CAGR and expected to reach $1.2 billion by 2020. This webinar reviews the current dynamics in the RNA therapeutics/vaccines market and focuses on process development and manufacturing strategies.

Feeding the Good Microbes: Unveiling the Effects of Diet and Nutrient Interactions on Pet Digestive Health
FEEDING THE GOOD MICROBES: UNVEILING THE EFFECTS OF DIET AND NUTRIENT INTERACTIONS ON PET DIGESTIVE HEALTH
Join Dr. Karl Dawson, vice president and chief scientific officer at Alltech, as he explains the effects of diet and nutrient interactions on digestive health. Due to the new awareness of the role that gastrointestinal microflora play in overall health, new nutritional strategies that influence micr...

Gene Therapy for Rare Diseases: Considerations for Both Clinical and Post-Marketing Studies
GENE THERAPY FOR RARE DISEASES: CONSIDERATIONS FOR BOTH CLINICAL AND POST-MARKETING STUDIES
There are approximately 7,000 distinct rare diseases affecting 350 million people worldwide, approximately 80 percent of which are caused by faulty genes. The US Food and Drug Administration (FDA) has more than 700 active Investigational New Drug Applications (INDs) for gene and cell therapies and i...

Predictive, Iterative and Adaptive Life Cycle Approaches: Managing Projects in the Knowledge Environment
PREDICTIVE, ITERATIVE AND ADAPTIVE LIFE CYCLE APPROACHES: MANAGING PROJECTS IN THE KNOWLEDGE ENVIRONMENT
This webinar will compare and contrast three (3) meaningful Life Cycle Approaches - Predictive, Iterative and Agile. In doing so, it will look at the implications of the ‘Knowledge Environment’ on the life cycle approaches and attempt to equip project management practitioners with the kn...

The Rising Demand for Trust & Transparency: Blockchain for Food
THE RISING DEMAND FOR TRUST & TRANSPARENCY: BLOCKCHAIN FOR FOOD
The global food system is growing rapidly, contributing to the abundance of choices available for consumers and adding complexity to the food supply chain. With numerous connection points and so many participants, there are greater chances for inefficiency, waste, and fraud. Consequently, innovators...

A Neuroscientist’s Guide to Live-Cell Analysis: Techniques & Benefits
A NEUROSCIENTIST’S GUIDE TO LIVE-CELL ANALYSIS: TECHNIQUES & BENEFITS
Despite exciting recent developments in neuroscience, identifying novel, truly effective treatments for patients with neurological and psychiatric conditions remains highly challenging. There is a high unmet need for more translational models and advanced analytical techniques that afford greater bi...

ESTIMATED CLINICAL AND ECONOMIC IMPACT OF REDUCING BLOOD CULTURE CONTAMINATION
ESTIMATED CLINICAL AND ECONOMIC IMPACT OF REDUCING BLOOD CULTURE CONTAMINATION
The impacts of blood culture contamination result in unnecessary antibiotic treatment, extended length of stay and increased hospital costs. Join Kevin Garey, professor and chair at University of Houston College of Pharmacy, as he discusses research findings recently published in the Journal of Clin...

A systems biology approach to unravelling the complexities of immune system development and function
A SYSTEMS BIOLOGY APPROACH TO UNRAVELLING THE COMPLEXITIES OF IMMUNE SYSTEM DEVELOPMENT AND FUNCTION
Immune systems are found in most living organisms. They reflect the common challenges of existing in a potentially hostile external environment and often exhibit a complex, ever-changing interplay between specialized cell types, potent effector molecules, and exogenously acquired molecules and organ...

Phenotyping the tumor micro-environment with advanced tissue-based multiplexing assays
PHENOTYPING THE TUMOR MICRO-ENVIRONMENT WITH ADVANCED TISSUE-BASED MULTIPLEXING ASSAYS
The benefits of multiplex immunohistochemistry assays for tissue analysis are numerous. High-level multiplexing, whole slide imaging, workflow compatibility, and spatial analysis are all must-have requirements for effective multiplex IHC solutions. This webinar will provide insight into how Ultivue&...

Profiling clonal hematopoiesis in cancer survivors with single-cell DNA sequencing
PROFILING CLONAL HEMATOPOIESIS IN CANCER SURVIVORS WITH SINGLE-CELL DNA SEQUENCING
Cure rates for children with cancer have increased dramatically over the past 40 years with the advent of modern treatment strategies, but most patients have serious life-long medical conditions as a result of the toxicity of their treatments. Clonal hematopoiesis of indeterminate potential (CHIP) i...

Big advance in contact-free movement of tiny amounts of liquid
BIG ADVANCE IN CONTACT-FREE MOVEMENT OF TINY AMOUNTS OF LIQUID
Acoustic liquid handlers have been available for more than a decade. They enable nanoliters of liquid to be accurately transferred from one well to another, without any risk of contamination or loss. The liquid handlers adapt to different fluid types and enable direct dilution of a liquid rather tha...

Magnetic 3D Bioprinting of Cells: Overcoming Imaging Obstacles in Spheroids
MAGNETIC 3D BIOPRINTING OF CELLS: OVERCOMING IMAGING OBSTACLES IN SPHEROIDS
Interest in 3D cell culture has grown exponentially in recent years, partially due to 3D cultures helping to overcome the challenges of using animal models and inadequacy of 2D cultures.  Challenges are still present because of the physical nature of 3D cultures, especially when using confocal ...

Insights into Recent Developments in Protein A Chromatography
INSIGHTS INTO RECENT DEVELOPMENTS IN PROTEIN A CHROMATOGRAPHY
Protein A-based chromatography is the primary method used to purify monoclonal antibodies (mAbs). Over the past decade, there has been significant development of Protein A media, resulting in both higher capacity and improved stability to meet the changing requirements of the industry. More improvem...

Utilizing Extracellular Matrix to Enhance Multicellular Tumor Spheroid Models for Proliferation and Invasion
UTILIZING EXTRACELLULAR MATRIX TO ENHANCE MULTICELLULAR TUMOR SPHEROID MODELS FOR PROLIFERATION AND INVASION
This technical video provides an overview of the methodologies, tools, and reagents used to generate multicellular tumor spheroids. Specifically, this video discusses the benefits of Cultrex® extracellular matrices for spheroid formation and analysis. Technical tips are provided for using colori...

A Systematic PDX-Based Solution for Preclinical Biomarker Discovery
A SYSTEMATIC PDX-BASED SOLUTION FOR PRECLINICAL BIOMARKER DISCOVERY
Tumor heterogeneity is a major hurdle for cancer treatment success. To effectively enroll patients in clinical trials, the identification of predictive biomarkers at the preclinical stage is crucial. The use of patient-derived xenograft (PDX) tumor models facilitates the identification of biomarkers...

3D Tumor Models: Predicting Better In Vivo and Translational Results
3D TUMOR MODELS: PREDICTING BETTER IN VIVO AND TRANSLATIONAL RESULTS
In a constant battle to find more efficient and effective ways to test oncology preclinical candidates, 3D in vitro culture methods for PDX-derived tumor cells have shown promise of in vivo-like growth characteristics, invasion, and responses to therapeutics. With these methods, we can perform high-...

MANAGING BIOLOGICS PROCESS ANALYTICAL TECHNOLOGY IN PFIZER
MANAGING BIOLOGICS PROCESS ANALYTICAL TECHNOLOGY IN PFIZER
Coordinating PAT between development and manufacturing organizations is always challenging. When there are multiple development sites and numerous manufacturing sites, this becomes especially challenging. In order to help manage this in an efficient manner, we have established a PAT SME network with...

Breaking Down Barriers in Healthcare: Urgency for the Clinical Laboratory to Migrate from the Background to the Forefront of Patient Care
BREAKING DOWN BARRIERS IN HEALTHCARE: URGENCY FOR THE CLINICAL LABORATORY TO MIGRATE FROM THE BACKGROUND TO THE FOREFRONT OF PATIENT CARE
The movement towards value-based healthcare has provided a platform for a better future for all involved in the health ecosystem. However, amongst the multitude of value initiatives, the clinical laboratory has largely been left to play a secondary role. Despite its core value principles of data, ti...

Knock out biologic quant and quality on a tiny sample
KNOCK OUT BIOLOGIC QUANT AND QUALITY ON A TINY SAMPLE
Collecting quantification and characterization data of biologics often requires a large amount of protein and multiple instruments. In this webinar, see how Lunatic makes batch-wise concentration measurements a breeze by using just 2 µL of sample and eliminating dilution steps and cross-contam...

Strategies to normalize miRNA expression in serum and plasma
STRATEGIES TO NORMALIZE MIRNA EXPRESSION IN SERUM AND PLASMA
MicroRNA(miRNA) are short non-coding single-stranded RNA molecules that regulate gene expression at the post-transcriptional level.  They are known to play a critical role in multiple biological processes including proliferation, differentiation, apoptosis, and hematopoiesis. Dysregulation of m...

It’s Never Too Late: Improve Clinical Trial Processes with a Unified Platform
IT’S NEVER TOO LATE: IMPROVE CLINICAL TRIAL PROCESSES WITH A UNIFIED PLATFORM
As scientific innovation has led to new trial designs, modern cloud technologies have enabled the industry to better manage how clinical trials are executed. Newer, more advanced cloud applications now offer unified data and process models, allowing organizations to manage their end-to-end clinical ...

Reconfirming the Group A Strep Diagnostic Algorithm with Molecular Confirmation
RECONFIRMING THE GROUP A STREP DIAGNOSTIC ALGORITHM WITH MOLECULAR CONFIRMATION
Group A Streptococcus (Group A Strep) remains fairly unchanged and is well-understood by the scientific community. However, our methods of detection have significantly improved as have various options for testing. With so many advancements in the landscape of molecular diagnostics, it is vital for a...

DNA Sequencing For Cancer Research
DNA SEQUENCING FOR CANCER RESEARCH
Through genomic sequencing and analysis, clinicians can identify specific mutations present in a patient’s cancer cells and deliver personalized treatment based on the genetic information. Increased availability and lower costs of next-generation sequencing (NGS) and analysis, along with the o...

Comprehensive Capture of Human Neuropathology by Multiplexed Ion Beam Imaging (MIBI)
COMPREHENSIVE CAPTURE OF HUMAN NEUROPATHOLOGY BY MULTIPLEXED ION BEAM IMAGING (MIBI)
Single cell analysis, starting with the earliest low parameter fluorescent experiments, helped define the major cell subsets of human cellular systems as we understand them today. Now, a novel combination of single cell analysis and metal isotopes based mass spectrometry (MIBI) offers a routine exam...

Soft Tissue Cancer-IHC Webinar
SOFT TISSUE CANCER-IHC WEBINAR
Soft tissue tumors are a broad group of neoplasms that involve the connective tissue of the body. Each year, over 13,000 people in the US are diagnosed with soft tissue sarcomas and over 5,000 people succumb to the malignancy. Because soft tissue sarcomas are very ambiguous and amorphous, many time ...

Lymphomas and Leukemias
LYMPHOMAS AND LEUKEMIAS
Leukemia and lymphoma are hematologic neoplasms that affect members of all age groups. Each year, over 140,000 people in the US are diagnosed with a hematologic malignancy of some kind. With constant advancement of treatment options, the importance of accurate diagnosis and detection of lymphomas an...

The Microbiome: Vital Cells of Existence
THE MICROBIOME: VITAL CELLS OF EXISTENCE
For every cell in your body, there’s another tiny single-celled creature that also calls your body home. Far from being germs, we should eradicate, these ancient friends allow us to digest food, breathe air, and fight off disease. They were here long before us and will undoubtedly remain long ...

Trends in Synthetic Biology: Antibody Engineering
TRENDS IN SYNTHETIC BIOLOGY: ANTIBODY ENGINEERING
As the body’s circulating army of first responders, antibodies recognize and destroy foreign and potentially disease-causing pathogens. The engineering of synthetic antibody forms and conjugates has produced a whole new arsenal of tools for applications in research, diagnostics, and therapeuti...

The Clinical Impact of TP53 Inclusion in Multi-Gene Panels
THE CLINICAL IMPACT OF TP53 INCLUSION IN MULTI-GENE PANELS
Multi-Gene panel-based genetic testing has emerged as the standard of care for cancer genetic testing. This has led to the identification of TP53 mutations among individuals without classic personal or family histories of Li-Fraumeni syndrome. These mutations may be due to mosaicism, clonal hematopo...

Talking to Patients about Genetic Testing and the Potential Psychosocial Implications of that Discussion
TALKING TO PATIENTS ABOUT GENETIC TESTING AND THE POTENTIAL PSYCHOSOCIAL IMPLICATIONS OF THAT DISCUSSION
Dr. Hurley will provide an overview of psychosocial challenges faced by patients deciding to undergo genetic testing.  Her presentation will combine research findings from psychosocial research and case illustrations from twenty years of providing psychotherapy to genetic counseling patients.&n...

Accelerating Biology: New Product Innovations from 10x Genomics
ACCELERATING BIOLOGY: NEW PRODUCT INNOVATIONS FROM 10X GENOMICS
Multicellular organisms and dynamic biological processes consist of a complex and coordinated interplay of multiple individual cells. Until recently, most molecular studies have relied on bulk analysis, combining all cells into a single average readout. In recent years, single-cell RNA sequencing te...

Seeing Beyond the Greyscale: Rapid Elemental Characterisation of Biological Samples
SEEING BEYOND THE GREYSCALE: RAPID ELEMENTAL CHARACTERISATION OF BIOLOGICAL SAMPLES
Precise identification and localization of molecules and organelles on the sub-cellular level are essential for a comprehensive understanding of key processes within biological samples. To achieve this, researchers utilize advanced microscopy techniques such as super-resolution microscopy and transm...

GENETICS IN YOUR CLINIC: WHAT YOU CAN AND SHOULD DO NOW
GENETICS IN YOUR CLINIC: WHAT YOU CAN AND SHOULD DO NOW
As we learn more about the contribution of genetic and genomic factors to the origin, natural history, and treatment of human disease, clinicians are assuming more responsibility for ordering genetic tests for their patients. This, plus the emergence of Precision Medicine and the growing availabilit...

A Virtual Destination for Laboratory Professionals
A VIRTUAL DESTINATION FOR LABORATORY PROFESSIONALS
Cardinal Health™ labXchange is a no-cost online destination where lab professionals have access to exhibits, live webinars and product demonstrations in one convenient location. Hear from leading experts on industry related topics - reimbursements, big data, emerging diseases, IQCP and more. I...

HUMANIZED MOUSE MODELS: APPLICATIONS IN ONCOLOGY AND INFECTIOUS DISEASE
HUMANIZED MOUSE MODELS: APPLICATIONS IN ONCOLOGY AND INFECTIOUS DISEASE
"Humanized mouse models, where human tumor tissue is engrafted into immunodeficient mouse models, are now being used in oncology and infectious disease studies to provide valuable translational insight. In this webinar, our panel of experts will discuss the successes and caveats of using humani...

Microbiology and Immunology 2018
MICROBIOLOGY AND IMMUNOLOGY 2018
Our 4th Annual Microbiology and Immunology Virtual Conference is now available On Demand! Participants will explore and discover new concepts, tools and techniques to apply to ongoing research and diagnostics. Microbiology and Immunology cover an array of industries and disciplines, encompassing var...

2019 Joint Commission National Patient Safety Goals: Update and Practical Advice
2019 JOINT COMMISSION NATIONAL PATIENT SAFETY GOALS: UPDATE AND PRACTICAL ADVICE
Understand the update of the National Patient Safety Goals to be sure your organization is in compliance with the requirements. Each year healthcare providers must meet the requirements of the Joint Commission's National Patient Safety Goals as part of the accreditation process. Receive an overv...

Ethical Considerations When Managing Patients
ETHICAL CONSIDERATIONS WHEN MANAGING PATIENTS' PAIN
Gain an understanding of how to help maintain the proper ethical pain management of patients. We are practicing in the midst of a national crisis in which every day over 130 people in the US die of overdosing from narcotic prescriptions overdose, heroin, and other related drugs. The pain was describ...

Flexible manufacturing strategies for cell and gene therapy products
FLEXIBLE MANUFACTURING STRATEGIES FOR CELL AND GENE THERAPY PRODUCTS
There is a clear call to automate manufacturing for cell and gene therapy products, but when should you automate? In this session, we will consider the shifting priorities as you move from product development towards clinical manufacturing and discuss how choosing the right type of automation can cr...

Laboratory Animal Sciences 2019
LABORATORY ANIMAL SCIENCES 2019
Digital transformation has affected the clinical phase of the drug development journey by improving efficiencies, patient engagement and allowing for utilization of computational and other technologies. This track will address topics such as data collection, flow, storage and analytics and digital t...

Better Science Through Imaging
BETTER SCIENCE THROUGH IMAGING
The Tilt from Mizar Imaging is a modular light sheet illumination system designed for high-resolution imaging. Mounting to most inverted microscopes, the Tilt enables light sheet imaging to be easily added to an existing or new microscope system. Existing light sheet microscopes use low(ish) NA dete...

The Secret to Improving the Therapeutic Index of Antibody Drug Conjugates
THE SECRET TO IMPROVING THE THERAPEUTIC INDEX OF ANTIBODY DRUG CONJUGATES
Antibody-drug conjugates (ADCs) were initially developed to provide a selective targeting mechanism for cytotoxic small molecule drugs with the goal of improving the therapeutic index in clinical practice. But despite a careful target selection and a high degree of specificity afforded through the a...

Virtual Clinical Trials Are Here: What Now?
VIRTUAL CLINICAL TRIALS ARE HERE: WHAT NOW?
Virtual or “siteless” clinical trials allow trial coordinators and patients to conduct clinical study visits via online video calls and collect data via handheld or wearable devices. In addition, virtual trials increase the size and diversity of the patient pool, accelerate recruiting, a...

Using CRISPR-Cas Screens to Reveal Fitness Genes and to Map Genetic Interactions
USING CRISPR-CAS SCREENS TO REVEAL FITNESS GENES AND TO MAP GENETIC INTERACTIONS
Genomic analyses are yielding a host of new information on the multiple genetic abnormalities associated with specific types of cancer. A comprehensive description of cancer-associated genetic abnormalities can improve our ability to classify tumors into clinically relevant subgroups and sometimes i...

Optimize This! Enhancing the Quality and Consistency of Cannabis and Extraction
OPTIMIZE THIS! ENHANCING THE QUALITY AND CONSISTENCY OF CANNABIS AND EXTRACTION
Everyone makes the best extracts. But are they optimized? And what does “the best” mean; does it mean high yield, high quality, or both? And what is quality anyway? Quality begins in the cultivation process and continues throughout the handling of the product from seed to sale. At OutCo,...

Is Your Biotherapeutic Immunomodulatory? How to Use Immunoassays to Get the Right Answer
IS YOUR BIOTHERAPEUTIC IMMUNOMODULATORY? HOW TO USE IMMUNOASSAYS TO GET THE RIGHT ANSWER
Biotherapeutics are a class of large medicinal products that are being increasingly used for various medical applications including vaccination, therapeutic drug delivery systems and the treatment of human diseases. Biotherapeutics offer the advantages of increased specificity and reduced toxicity c...

Characterization of Extracellular Vesicles with Nanoscale Flow Cytometry
CHARACTERIZATION OF EXTRACELLULAR VESICLES WITH NANOSCALE FLOW CYTOMETRY
In this webinar, we will discuss how to set up and utilize a flow cytometer for nanoparticle analyses.  We will first describe how to properly set up and clean a flow cytometer for small-particle experiments.  Next, we will characterize the scatter and fluorescence sensitivity of the CytoF...

MicroRNAs as biomarkers and therapeutic targets in TNBC
MICRORNAS AS BIOMARKERS AND THERAPEUTIC TARGETS IN TNBC
Triple-negative breast cancer accounts for a disproportionate share of the total breast cancer morbidity rate due to its aggressive behavior and lack of effective targets. Join Dr. Brian Adams of Harvard Medical School as he discusses how microRNAs can serve as superior therapeutic agents in th...

Tau Biology and Pathology in and Beyond Alzheimer’s Disease
TAU BIOLOGY AND PATHOLOGY IN AND BEYOND ALZHEIMER’S DISEASE
Watch this on-demand webinar presented by Dr. Akihiko Takashima and Dr. Ioannis (John) Sotiropoulos and learn about the emerging views on the role and function of Tau in neurons - including its recently suggested contributions to scaffolding and signaling. 

Triple Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer
TRIPLE NEGATIVE BREAST CANCER RISK GENES IDENTIFIED BY MULTIGENE HEREDITARY CANCER
In this webinar, Dr. Couch will present results from a recent study of multigene hereditary cancer panel testing in >10,000 women with triple-negative breast cancer (TNBC), focusing on the prevalence of cancer gene mutations among TNBC cases along with gene-specific associations with TNBC among C...

Genomics and the Future of Human Reproduction
GENOMICS AND THE FUTURE OF HUMAN REPRODUCTION
For most of humanity’s existence, we had only one way to make babies. The last century or so have seen the beginnings of change, with artificial insemination, in vitro fertilization, and prenatal and preimplantation genetic testing. The rest of this century will see astonishing changes, made b...

Maize genome complexity traversed with Oxford Nanopore technology
MAIZE GENOME COMPLEXITY TRAVERSED WITH OXFORD NANOPORE TECHNOLOGY
Maize is one of the most economically important crops globally and much effort has been spent generating the high quality B73 reference genome. However, the 10 chromosome, 2.3 gigabase (Gb) B73 reference genome was a substantial challenge due to the fact it is comprised of 85% transposable elements,...

Food Safety Management Systems to Enhance Customer Experience
FOOD SAFETY MANAGEMENT SYSTEMS TO ENHANCE CUSTOMER EXPERIENCE
Restaurant cleanliness matters! It’s the most important driver of customer visitation (i.e., they come back more often and increase sales) and brand loyalty, just behind the importance of employee service and food quality attributes. Employee service, “cleanliness“, and how the emp...

Assessing Treatment Benefit in Immuno-Oncology
ASSESSING TREATMENT BENEFIT IN IMMUNO-ONCOLOGY
The management of cancer patients in clinical practice is undergoing a revolution due to the introduction of effective immunotherapy. Several different strategies currently rely on harnessing the immune system to fight tumors, leading to unprecedented therapeutic success. However, immunotherapy has ...

Targeting prostate cancer stem cells with T cell immunotherapy
TARGETING PROSTATE CANCER STEM CELLS WITH T CELL IMMUNOTHERAPY
In healthy tissue, a reservoir of stem cells gives rise to non-stem cells while simultaneously maintaining their own population. This enables potentially endless growth and recovery from damage. Cancer stem cells (CSC) sustain cancer growth in the same way as normal stem cells do in healthy tissues....

Novel Continuous and Manual Sampling Methods for Beef Trim Microbiological Testing
NOVEL CONTINUOUS AND MANUAL SAMPLING METHODS FOR BEEF TRIM MICROBIOLOGICAL TESTING
A new beef trim sampling concept has been developed through a joint R&D project with USDA Agricultural Research Service, Fremont, and Sentry Equipment. The methods developed from this effort have received a USDA Letter of No Objection. For beef trimmings, potential contaminants will be on t...

Food Adulteration Detection: Getting Out of the Lab Using Portable Spectroscopy
FOOD ADULTERATION DETECTION: GETTING OUT OF THE LAB USING PORTABLE SPECTROSCOPY
Food fraud is estimated to cost the world economy more than $49 billion per year. The 2013 horse meat scandal alone was reported to cost the UK economy more than £1 billion. The effects of food adulteration reach much further than just these serious economic consequences. The Chinese infant fo...

Key Considerations for the Successful Development of a Biologic: Seven Steps to Success
KEY CONSIDERATIONS FOR THE SUCCESSFUL DEVELOPMENT OF A BIOLOGIC: SEVEN STEPS TO SUCCESS
Understanding the biology of your therapeutic is key to effectively and efficiently progressing it from first principles, through safety assessment studies, and into clinical trials. The unique characteristics and specific biology of each large molecule therapeutic make it impossible to design a &ld...

EXTRACTABLES FROM SINGLE-USE BIOREACTORS/BAGS AND IMPACT ON CELL CULTURE PERFORMANCE
EXTRACTABLES FROM SINGLE-USE BIOREACTORS/BAGS AND IMPACT ON CELL CULTURE PERFORMANCE
Attribute Sciences, Process Development, Amgen Biopharmaceuticals are drugs manufactured by growing genetically engineered cells in bioreactors to produce a therapeutic protein. Plastic single-use bioreactors are of interest to biopharmaceutical drug manufacturers due to their significant environmen...

Turning Up the Volume on Cell Therapy Production
TURNING UP THE VOLUME ON CELL THERAPY PRODUCTION
The development of novel biotherapeutics is an essential element in generating the power to cure the incurable. With recent advances in cell and molecular biology, cell therapy has emerged as an effective means to treat a host of biological disorders. However, challenges remain for the clinical and ...

High Throughput, Low Volume Subvisible Particle Analysis
HIGH THROUGHPUT, LOW VOLUME SUBVISIBLE PARTICLE ANALYSIS
Subvisible particle analysis is a key predictor of protein drug stability and a key formulation, quality metric. However, current methods use large volumes of precious protein solutions and are labor- and time-intensive, making this data inaccessible during late-stage candidate screening or early in...

Multiplexing PCR Design Made Easy
MULTIPLEXING PCR DESIGN MADE EASY
Because of its reliability, sensitivity and low cost, PCR has become the backbone of modern diagnostics. In recent years, researchers have ingeniously capitalized on the fundamental nature of PCR through multiplexing reactions saving reagent costs, precious samples, and user time. Multiplexing has a...

The Cell Culture Revolution: Commercializing Therapeutic Cell Systems
THE CELL CULTURE REVOLUTION: COMMERCIALIZING THERAPEUTIC CELL SYSTEMS
The advent of recombinant antibody production in mammalian cell lines has revolutionized modern medicine. Clinical success of these agents has challenged the underlying biological manufacturing systems to produce quantities sufficient to supply the ever-expanding commercial markets. A fundamental fo...

Using Peptones to Achieve Diverse and Demanding Bioproduction Goals
USING PEPTONES TO ACHIEVE DIVERSE AND DEMANDING BIOPRODUCTION GOALS
As bioproduction requirements advance, it is critical to have consistent, high-quality media and supplements that continue to meet evolving industry needs. Peptones have been successfully used in bioproduction applications for more than 30 years to meet diverse and demanding production requirements....

High-Throughput Multiplexed Screening of TCR Signaling Inhibitors
HIGH-THROUGHPUT MULTIPLEXED SCREENING OF TCR SIGNALING INHIBITORS
T cells play a critical role in the adaptive immune response. In naive T cells, binding of the T-cell receptor (TCR) to peptides complexed with major histocompatibility complex triggers an intricate signaling mechanism leading to T-cell activation, proliferation, and production of cytokines. Modulat...

Characterization of Oral Gut-Selective vs. Systemic JAK Inhibitors in the Mouse Oxazolone Colitis Model
CHARACTERIZATION OF ORAL GUT-SELECTIVE VS. SYSTEMIC JAK INHIBITORS IN THE MOUSE OXAZOLONE COLITIS MODEL
Autoimmune diseases such as ulcerative colitis require chronic treatment that often causes systemic immunosuppression, increasing long term cancer and infection risk. Reducing systemic side effects with localized treatment would greatly benefit patients. This webinar will explore the spatial charact...

Current Landscape of Education for Genetic Counselors
CURRENT LANDSCAPE OF EDUCATION FOR GENETIC COUNSELORS
Although the genetic counselor workforce has grown by 88% in the past 10 years, a 2016 supply and demand report confirmed that the US is currently experiencing a shortage of genetic counselors engaged in direct patient care (Hoskovec et al., 2017). In response, there are a variety of efforts underwa...

RNA-Seq as a Complement to DNA Genetic Testing
RNA-SEQ AS A COMPLEMENT TO DNA GENETIC TESTING
In this presentation, Dr. Karam will summarize RNA-sequencing technologies. The focus of the presentation will be describing the use of these technologies to aid understanding and diagnosing genetic disease. Rachid obtained his medical degree in Brazil, at the Federal University of Health Scien...

Comprehensive Variation at Clinical-Population Scales
COMPREHENSIVE VARIATION AT CLINICAL-POPULATION SCALES
Precision medicine anticipates the clinical application of whole-genome sequencing (WGS), as evidenced by the commitment of large-scale clinical programs such as All of Us for generating and reporting WGS data for millions of individuals. Execution of the required data analysis, from sample accessio...

Novel Approaches to Quantitative Metabolomics
NOVEL APPROACHES TO QUANTITATIVE METABOLOMICS
A frequently challenging field, metabolomics is often considered the most direct approach to making quantitative measurements that can be related to the physiological state of an organism. In this exclusive online symposium, you will discover new and novel approaches to quantitative metabolomics as ...

Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
USING MICRO-CT IMAGING FOR THE PHENOTYPING AND ANALYSIS OF BONE ARCHITECTURE
Micro-computed tomography (micro-CT) offers significant advantages over other X-ray imaging techniques in the field of bone research. Its high-level X-ray absorption enables good contrast and the ability to observe bone in very fine detail, not only in bone density studies but also those examining t...

Expanding Biobanking Size and Scope to Advance Big Data Discovery
EXPANDING BIOBANKING SIZE AND SCOPE TO ADVANCE BIG DATA DISCOVERY
Currently, the Cleveland Clinic Biorepository is an assembly of several biobanks together with the Lerner Research Institute. Excel spreadsheets track almost everything – and there are no universal LIS, SOPs, universal, centralized freezer monitoring, or means to electronically track patient t...

ADVANCES AND CHALLENGES IN VACCINE DEVELOPMENT AND MANUFACTURE
ADVANCES AND CHALLENGES IN VACCINE DEVELOPMENT AND MANUFACTURE
This webinar reviews the constraints and complexities of vaccine product development and manufacture. The evolution of bioprocess and analytics innovation and technologies to overcome these challenges are discussed. The strategy and leveraging of innovation and technology for rapid product developme...

Risk stratification of the apparently healthy population with ARCHITECT STAT High Sensitive Troponin-I
RISK STRATIFICATION OF THE APPARENTLY HEALTHY POPULATION WITH ARCHITECT STAT HIGH SENSITIVE TROPONIN-I
In this webinar, you will hear about a recently CE marked application for ARCHITECT STAT High Sensitive Troponin I, that aids in providing greater accuracy for estimation of risk for future cardiac events in apparently healthy people, when used in conjunction with clinical and diagnostics findings. ...

Medicare Provider Agreement Assignment Following Change of Ownership: Evaluating Automatic Assignment vs. Rejection
MEDICARE PROVIDER AGREEMENT ASSIGNMENT FOLLOWING CHANGE OF OWNERSHIP: EVALUATING AUTOMATIC ASSIGNMENT VS. REJECTION
This CLE webinar will guide healthcare counsel on navigating a change of ownership (CHOW) in healthcare transactions when Medicare provider agreements are involved. The panel will discuss the factors to consider when determining whether to accept or reject the assignment of the provider agreement an...

CRISPR-created Animal Models: The Technical Lowdown
CRISPR-CREATED ANIMAL MODELS: THE TECHNICAL LOWDOWN
Creating reproducible animal models for long-term studies can often be problematic due to the complexity of the genetic modification(s) required. Suboptimal design strategies compound the challenges by generating undesired genotypic or phenotypic results. CRISPR-Cas9 or zinc-finger nuclease (ZFN)-ba...

Cell Signaling and Metabolism: Bridging a Gap in Cancer Therapies
CELL SIGNALING AND METABOLISM: BRIDGING A GAP IN CANCER THERAPIES
That cancer cells display an altered metabolism has been known for almost a century, but the cell-signaling mechanisms responsible for this phenomenon are just beginning to be understood, with some drugs targeting key regulators of both cell metabolism and tumor progression. The repurposing of old d...

The Brain-Microbiome Axis: Links Between Neurological Disease and Microbiota
THE BRAIN-MICROBIOME AXIS: LINKS BETWEEN NEUROLOGICAL DISEASE AND MICROBIOTA
The human microbiome consists of trillions of commensal microbes. These include bacteria, fungi, and viruses, which naturally reside within the human body and have been documented to affect epigenetic mechanisms, metabolic activity, and immune system function. Researchers are now focusing on how mic...

Stem Cells: Opportunities, Hurdles, and Promises
STEM CELLS: OPPORTUNITIES, HURDLES, AND PROMISES
Since Sir. Martin Evans’ 1981 identification of embryonic stem cells in mice, stem cells have been at the center of the drive to revolutionize medicine and the drug discovery process. In 1998, human embryonic stem cells were grown in a lab, and the field was further boosted in 2006 with the pi...

CURRENT USP PERSPECTIVES ON A RAPID STERILITY TEST
CURRENT USP PERSPECTIVES ON A RAPID STERILITY TEST
The current growth-based Sterility Tests with at least 14-days incubation is not suitable for short-lived products. An expert panel was formed under the USP General Chapters– Microbiology Expert Committee to provide recommendations on user requirements specifications and candidate technologies...

Botanical Identification - Authentication vs Adulteration
BOTANICAL IDENTIFICATION - AUTHENTICATION VS ADULTERATION
This webinar addresses the complex methods of botanical identification of natural nutraceutical and functional foods, and how adulteration of substances is discovered. It’s an exciting journey through the realm of chemical marker compounds, ratio comparison, and the latest in quality assurance...

The 3 R’s of cancer therapy: Response, Resistance, and Relapse
THE 3 R’S OF CANCER THERAPY: RESPONSE, RESISTANCE, AND RELAPSE
The 3 R’s: Response, Resistance, and Relapse Simplistic View of Cancer: a Monolith Patterns of response and resistance. Tumors Have Many Clones. Not One 4 identical mutations shared by one region of the chest wall and perinephric metastasis Darwinian Selection and Branched Evolution Mutation V...

Recent advances in diagnostics and treatments - from small molecules to cellular therapies
RECENT ADVANCES IN DIAGNOSTICS AND TREATMENTS - FROM SMALL MOLECULES TO CELLULAR THERAPIES
The majority of clinically approved medicines are synthetic small molecules that modulate target activity, usually by inhibiting the function of a single protein. A fraction of these small molecule medicines exert their therapeutic effect by activating protein targets and disrupting protein-protein ...

IS INDIA ANYWHERE CLOSER TO IMPLEMENTING CONTINUOUS BIOPROCESSING
IS INDIA ANYWHERE CLOSER TO IMPLEMENTING CONTINUOUS BIOPROCESSING
Continuous processing has been widely employed in many biological manufacturing processes. In recent years it gained the momentum in the field of Biosimilar manufacturing due to an ever-increasing pressure for reduction in manufacturing costs. Potentially, the continuous processing offers Lower Cost...

MIXED MODE CHROMATOGRAPHY IN PURIFYING BIOLOGICS – OVERVIEW
MIXED MODE CHROMATOGRAPHY IN PURIFYING BIOLOGICS – OVERVIEW
The market for therapeutic proteins such as monoclonal antibodies (mAbs), growth hormones, other recombinant therapeutic proteins has grown tremendously in the last two decade. To compete in the biopharmaceutical market, we should identify, develop the high product producing clone and find the best ...

EVOLVE MANUFACTURING PROCESSES BY IMPLEMENTING DISRUPTIVE TECHNOLOGIES
EVOLVE MANUFACTURING PROCESSES BY IMPLEMENTING DISRUPTIVE TECHNOLOGIES
The desire for innovative technology that can eventually cause disruptive changes remains high in the biotech pharmaceutical industry. The road between pursuing and developing that technology to genuine implementing is not a smooth ride. In this webinar, the presenter identifies key challenges of im...

Recent Changes to Drug Approvals in China: Regulatory Consultation, IND Submission and Acceptance of Foreign Data in NDA
RECENT CHANGES TO DRUG APPROVALS IN CHINA: REGULATORY CONSULTATION, IND SUBMISSION AND ACCEPTANCE OF FOREIGN DATA IN NDA
Historically, the review and approval of a Chinese investigational new drug (IND) have taken a year or even longer to complete, and new drug application (NDA) approval for a new drug lagged behind Western countries by four or five years. Recently, the National Medical Products Administration announc...

Simplifying Clinical Data Flow from EDC to SDTM
SIMPLIFYING CLINICAL DATA FLOW FROM EDC TO SDTM
Recent trends in clinical trials – including the increasing availability of clinical, operational and real-world data streams – offer the opportunity to gain better insight over clinical R&D as never before, but poses interesting challenges with data aggregation, harmonization, and c...

Endodontic applications of microcomputed tomography for studying root canals
ENDODONTIC APPLICATIONS OF MICROCOMPUTED TOMOGRAPHY FOR STUDYING ROOT CANALS
Endodontics is a specialty within the field of dentistry concerned with the morphology, physiology, and pathology of the human dental pulp and periradicular tissues. Recent technological advancements have led to several new methods for visualizing the anatomy of the human teeth, but, over the last d...

Molecular Testing Guideline for Selection of Lung Cancer Patients
MOLECULAR TESTING GUIDELINE FOR SELECTION OF LUNG CANCER PATIENTS
The advent of targeted therapies based on predictive biomarkers has dramatically altered the role of the molecular pathologist in lung cancer patient care. This webinar reviews the new recommendations published in the revised 2018 CAP/IASLC/AMP lung cancer predictive biomarker guidelines (Lindeman e...

Genetics and Genomics 2018
GENETICS AND GENOMICS 2018
Our 6th Annual Genetics and Genomics Virtual Conference are now available On Demand! As the foundation of life, genetics provides a base for other sciences to grow from. This free on-demand event will cover the most recent and exciting advances in genetics research. Participants of the Genetics 2018...

Drug Development – The 6 Most Critical Reasons Why Drugs are Delayed When Planning and Conducting CTA/IND Enabling Studies
DRUG DEVELOPMENT – THE 6 MOST CRITICAL REASONS WHY DRUGS ARE DELAYED WHEN PLANNING AND CONDUCTING CTA/IND ENABLING STUDIES
Bringing a drug from discovery to market is an expensive and time-consuming business. Every drug that fails comes with a cost which could be both reputational and financial. Keeping your development program on track is therefore critical to success. In this webinar, our featured speaker will explore...

Telehealth drug prescribing & the opioid crisis: What every doctor needs to know
TELEHEALTH DRUG PRESCRIBING & THE OPIOID CRISIS: WHAT EVERY DOCTOR NEEDS TO KNOW
Why is there a good chance you're illegally prescribing medication over telehealth? How are telehealth prescribing rules changing with the opioid crisis? Is an in-person exam necessary for prescribing medication online? How does telehealth drug prescribing work across state lines or internationa...

Stunner bangs out protein quant and characterization in one shot
STUNNER BANGS OUT PROTEIN QUANT AND CHARACTERIZATION IN ONE SHOT
Quantification and quality measurements are both integral parts of protein characterization workflows. These parameters have previously been collected separately, simply due to the lack of tools that can measure both. In this webinar, Dr. Lisa Adamiak will discuss how Stunner enables researchers to ...

Advanced optical hematology technology for elevated analytical performance
ADVANCED OPTICAL HEMATOLOGY TECHNOLOGY FOR ELEVATED ANALYTICAL PERFORMANCE
Today, hematology analyzers can collect vast amounts of data about cell characteristics, that subsequently improve disease detection. Advanced systems can perform a complete blood count (CBC) and classify multiple cell types, including more than the normal five subclasses of mature white blood cells...

Current Controversies in the Epidemiology, Diagnosis, and Management of Vaginal Infections
CURRENT CONTROVERSIES IN THE EPIDEMIOLOGY, DIAGNOSIS, AND MANAGEMENT OF VAGINAL INFECTIONS
Vaginal infections are a source of considerable morbidity among women. It is estimated that there are more than 10 million office visits per year due to vaginal infections. The three main causes of infectious vaginitis are vulvovaginal candidiasis (VVC), trichomoniasis, and bacterial vaginosis (BV)....

Transforming Clinical Trial Operations: The Next Big Step
TRANSFORMING CLINICAL TRIAL OPERATIONS: THE NEXT BIG STEP
Research shows that today’s clinical technology landscape is siloed, prompting an industrywide move to unify clinical trial systems and streamline end-to-end processes for better visibility and improved study execution. In a recent industry survey, 99% of respondents reported the need to unify...

Oncology Drug Access Navigators - Benefits to Patients & Health Care Teams
ONCOLOGY DRUG ACCESS NAVIGATORS - BENEFITS TO PATIENTS & HEALTH CARE TEAMS
Alan Birch discussed the role of an Oncology Drug Access Navigator as well as how the role fits into the healthcare team and what they help patients with. He gave a brief overview and history of the role as well as discussing challenges faced by patients and how National Pharmacare may impact it all...

Drug Discovery 2018
DRUG DISCOVERY 2018
Despite the rapid pace of scientific advances that garner a better understanding of a myriad of diseases on their molecular level, modern drug discovery is a long, complex process. As to be expected, the course of action for researching and developing new medicines is growing in difficulty and lengt...

Neuroscience 2018
NEUROSCIENCE 2018
Our  6th Annual world-renowned Neuroscience virtual conference is now available On Demand! Neuroscience 2018 aims to explore the mechanisms of neural function from the molecular to the network level in health and disease. World-renowned experts and thought leaders discussed the dynamics of brai...

Solving Medical Technology Product Development Issues
SOLVING MEDICAL TECHNOLOGY PRODUCT DEVELOPMENT ISSUES
There is an increasing number of emerging medical technologies (MedTech) which are having a significant effect on the medical equipment and medical device industries. The main principles that come into play when applying these new medical technologies are design for manufacturability, thinking ahead...

Recent Technological Advancements in Medical Communication
RECENT TECHNOLOGICAL ADVANCEMENTS IN MEDICAL COMMUNICATION
Join this webinar for a discussion of the most common medical communications business challenges and potential solutions. This event will also feature a live demonstration of how patient-centric medical communications technology can be leveraged to streamline and optimize medical inquiry fulfillment...

Clinical Supply Planning Optimization
CLINICAL SUPPLY PLANNING OPTIMIZATION
This webinar provides a comprehensive overview of the current supply planning landscape, identifies gaps which are inhibiting supply professionals from optimizing their supply chains and delves into solutions for driving efficiencies from a people, process and technology perspective. Also to be disc...

How to Solve Big Challenges in Small Biotechs Using Big Data Analytics
HOW TO SOLVE BIG CHALLENGES IN SMALL BIOTECHS USING BIG DATA ANALYTICS
Small biotechs are the engine of scientific innovations in the biopharmaceutical industry. However, they are saddled with many of the challenges facing big companies such as data silos and challenges to quick access to information critical to managing their clinical trials. This is manifested by the...

3D Organ-on-a-chip Applications Using the AIM Biotech Chip
3D ORGAN-ON-A-CHIP APPLICATIONS USING THE AIM BIOTECH CHIP
In the vitro 3D cell, culture models have emerged as a bridge between conventional 2D cell culture models and the complex & expensive in vivo animal models. By analyzing and comparing the biological behavior of tissues embedded in 3-dimensional hydrogels, results are significantly different from...

Intellectual Property in biotech: from bioprinting to bedside
INTELLECTUAL PROPERTY IN BIOTECH: FROM BIOPRINTING TO BEDSIDE
TeVido BioDevices uses the innovative process of 3D bioprinting living human cells for use as implants or grafts for use in reconstructive surgery and wound care, for example in post-surgery care for cancer patients. TeVido uses a simple yet sophisticated approach to produce living tissue produ...

Patient-Centric IRT Management for Compassionate Use Studies
PATIENT-CENTRIC IRT MANAGEMENT FOR COMPASSIONATE USE STUDIES
When developing lifesaving medications for patients is at your core, it is essential to streamline the processes of managing the critical clinical supplies and trial data through advanced technology. The pooled clinical supply approach, when coupled with a comprehensive control system, offers unique...

Harmonising drug-target binding data analytics on a single platform
HARMONISING DRUG-TARGET BINDING DATA ANALYTICS ON A SINGLE PLATFORM
In early-stage medicines research, measuring in vitro drug-target interaction characteristics is a critical path activity in selecting therapeutic candidates for progression into pre-clinical models. Technologies and instrumentation used in this space are numerous. Bespoke instrument-specific data a...

High throughput screening for deep mining of antibody repertoires
HIGH THROUGHPUT SCREENING FOR DEEP MINING OF ANTIBODY REPERTOIRES
Antibodies are the key drivers of new drug development based on biologics rather than small molecules. Multiple blockbuster drugs have emerged in this area, many more are in the pipeline. In this webinar, Stefan Moese talks about the implementation of a high throughput screening approach for mining ...

Analytical Chemistry 2018
ANALYTICAL CHEMISTRY 2018
The field of analytical chemistry is focused on advancements in experimental design, chemometrics, and the creation of new analytical instrumentation. Analytical chemistry has broad applications into forensics, environmental testing, pharmacological developments, material science, and engineering.&n...

Fit-for-Future Pharmacovigilance Sourcing Strategies
FIT-FOR-FUTURE PHARMACOVIGILANCE SOURCING STRATEGIES
The challenges and demands of pharmacovigilance in today’s climate has shifted significantly. How do we determine what should and can be sourced differently compared to our traditional models? Offshore-outsourced blended models are becoming increasingly popular. Join this webinar for a discuss...

Nuclear Imaging of CNS Diseases in Rodent Models
NUCLEAR IMAGING OF CNS DISEASES IN RODENT MODELS
Nuclear imaging provides translational and noninvasive in vivo methodology to reliably quantify pathological changes during disease progression and allows evaluation of therapeutic effects of existing or novel drugs against the disease. This webinar showcases new developments of CNS Discovery Servic...

Inhalation Drug Delivery: Considerations for Toxicology and Pharmacology Research
INHALATION DRUG DELIVERY: CONSIDERATIONS FOR TOXICOLOGY AND PHARMACOLOGY RESEARCH
Drug delivery to the lungs in both the clinical and non-clinical setting is a unique combination of formulation, the delivery device and the system/model that the drug is being delivered to. Throughout different stages of drug development, the requirements for inhalation drug delivery change and the...

Getting the Most Out of Interactive Response Technology in Clinical Trial Supply
GETTING THE MOST OUT OF INTERACTIVE RESPONSE TECHNOLOGY IN CLINICAL TRIAL SUPPLY
Increasingly complex, international clinical trials demand a smart, comprehensively planned approach. With the correct interactive response technology (IRT) system in place, you have a powerful tool for accelerating your product’s progress to launch.  While IRT manages patient interaction...

Pediatric Cancer Genomics: Accessing Data, Tools and Visualizations in St. Jude Cloud
PEDIATRIC CANCER GENOMICS: ACCESSING DATA, TOOLS AND VISUALIZATIONS IN ST. JUDE CLOUD
Next-generation genomic sequencing is transforming what is known about pediatric cancer and how we treat patients. But even with new technologies, challenges remain. In the past, the sheer size of genomics data has made sharing across the global scientific community a challenge. St. Jude Cloud is a ...

Better Target Validation for Drug Discovery with CRISPR/Cas9
BETTER TARGET VALIDATION FOR DRUG DISCOVERY WITH CRISPR/CAS9
Better target validation is a key driver of better productivity in drug discovery. The RNA-guided nucleases, exemplified by Cas9, represent a powerful new approach to understanding gene function and, in principle, to reveal the next generation of therapeutic targets. But how well does this technolog...

Transforming translational research: CANscript–A better predictive model for oncology
TRANSFORMING TRANSLATIONAL RESEARCH: CANSCRIPT–A BETTER PREDICTIVE MODEL FOR ONCOLOGY
In this webinar, speaker Mark Paris, Ph.D. discussed a recent study evaluating a cohort of HNSCC patient tumors treated with anti-PD1 using CANscript™. He also is reviewed the results of this study as a means of investigating predictors of clinical response and identifying mechanisms of resist...

Starting a Third Party Analytical Laboratory in the Cannabis Industry
STARTING A THIRD PARTY ANALYTICAL LABORATORY IN THE CANNABIS INDUSTRY
In this webinar, we will explore the challenges and opportunities of starting a third-party testing laboratory in the cannabis industry. Seth Wong, a 15-year seasoned laboratory executive, will walk us through his experience starting a new ISO/IEC 17025 analytical lab on the University of Colorado A...

Proving the Strategic Value of Patients
PROVING THE STRATEGIC VALUE OF PATIENTS
Patient insights aren’t just a ‘nice to have’: they are essential to understanding the space where Pharma’s drugs ‘live’. On the 10th October, Cello Health Insight in association with PMGroup will look at the value of three areas of patient research that provide t...

The mast cell receptor MrgX2 and drug-induced anaphylaxis
THE MAST CELL RECEPTOR MRGX2 AND DRUG-INDUCED ANAPHYLAXIS
Activation of MrgX2, a GPCR expressed on mast cells, leads to degranulation and histamine release. MrgX2 binds promiscuously to basic peptides and small molecules, resulting in acute histamine-like adverse drug reactions, both in man and in mammalian species used in drug toxicology. The goal of this...

Realising the biotech promise: addressing the path to market
REALISING THE BIOTECH PROMISE: ADDRESSING THE PATH TO MARKET
Now more than ever before, Biotech is the engine for innovation in medicine, finding, creating and delivering ground-breaking treatments to patients. The journey from molecule discovery and development through valuation, funding, regulatory and commercialization can be a long and complex road to tra...

Identify and Quantify Individual Host Cell Proteins
IDENTIFY AND QUANTIFY INDIVIDUAL HOST CELL PROTEINS
ELISA is the golden standard for HCP analysis but has some drawbacks. It only provides a single number (ng HCP/mg drug substance) and no information about the specific HCP’s. Here we present an HCP analysis method based on a SWATH LC-MS that provides reproducible identification and absolute qu...

Association of Biotin Ingestion with Performance of Hormone and Nonhormone Assays in Healthy Adults
ASSOCIATION OF BIOTIN INGESTION WITH PERFORMANCE OF HORMONE AND NONHORMONE ASSAYS IN HEALTHY ADULTS
High dose of biotin may cause interference with many routine clinical immunoassays and inaccurate results of some of the tests such as cardiac troponin have serious clinical complications. There is an increasing trend of high dose biotin supplement use in the US population, although the exact preval...

Good culture for your cells - Best practices for preventing contamination
GOOD CULTURE FOR YOUR CELLS - BEST PRACTICES FOR PREVENTING CONTAMINATION
Are ethanol and antibiotics the best measures to prevent microbial contamination? Contamination is an everyday challenge in cell culture labs. Undetected or ignored contamination endanger the reliability and reproducibility of experimental data.  Get to know the most effective methods to detect...

The Future of Marketing in Life Sciences: Is your function fit for purpose?
THE FUTURE OF MARKETING IN LIFE SCIENCES: IS YOUR FUNCTION FIT FOR PURPOSE?
The healthcare landscape is rapidly changing as it responds to a multitude of well-known issues. Coupled with emerging digital technologies, these drivers are shaping the industry, moving it towards a more sophisticated, outcomes-driven model that demands a new approach. The new world emerging is on...

CRISPR 2018
CRISPR 2018
With continued adoption and integration in research labs, CRISPR gene editing has gained importance both as a research tool in drug discovery, screening, and therapeutic development. This inaugural event will bring together thought leaders from academia, trained researcher from clinical laboratories...

Improving hepatocyte activity, pooling and lab efficiency
IMPROVING HEPATOCYTE ACTIVITY, POOLING AND LAB EFFICIENCY
CryostaX® hepatocytes are created using a patented process that produces unique single-donor cell pellets. This format allows for distinct benefits to hepatocyte performance, efficiency in the lab, and test system design, precipitating the potential discontinuation of cryopreserved hepatocytes p...

Quantify Intact Virus Particles More Precisely And Faster Than qPCR
QUANTIFY INTACT VIRUS PARTICLES MORE PRECISELY AND FASTER THAN QPCR
An analytical quality by design (AQbD) approach was embraced for the development of a capillary zone electrophoresis (CZE) method for the quantification of intact virus particles. With CE, the intact adenovirus particles were separated from sample matrix components such as cell debris, residual cell...

Laboratory Animal Sciences 2018
LABORATORY ANIMAL SCIENCES 2018
The 7th annual Laboratory Animal Sciences (LAS) virtual conference is now available on-demand! The LAS Planning Committee, led by Dr. Szczepan Baran, Global Head of Animal Welfare and Compliance Training at Novartis Pharmaceuticals, and composed of more than 20 world-renowned experts, will plan and ...

Using AI and IoT to Accelerate Research
USING AI AND IOT TO ACCELERATE RESEARCH
A serial entrepreneur in sensors, IoT, medical devices, and wearables, Sridhar is founded Elemental Machines with the mission to build products to help science-based companies decipher and understand physical processes from R&D to manufacturing. Previously, Sridhar was a founder of Misfit, maker...

Skin toxicity mechanisms associated with mGluR5 negative allosteric modulators
SKIN TOXICITY MECHANISMS ASSOCIATED WITH MGLUR5 NEGATIVE ALLOSTERIC MODULATORS
Cutaneous reactions represent one of the most common adverse drug effects observed in clinical trials leading to substantial compound attrition. In this webinar, Falgun Shah discussed three negative allosteric modulators of metabotropic glutamate receptors, developed by Pfizer, which recently failed...

Improving Intact Antibody and Plasma Glycoprotein Analysis with Native MS and Parsimonious Charge Deconvolution
IMPROVING INTACT ANTIBODY AND PLASMA GLYCOPROTEIN ANALYSIS WITH NATIVE MS AND PARSIMONIOUS CHARGE DECONVOLUTION
Recent developments in mass spectrometry technology have enabled the analysis of intact native glycoproteins and protein complexes using Orbitrap mass analyzers with extended mass ranges  (EMR). High sensitivity and resolution enable the profiling of critical quality attributes and biosimilarit...

Defects in potassium channels contribute to reduced immune surveillance in cancers
DEFECTS IN POTASSIUM CHANNELS CONTRIBUTE TO REDUCED IMMUNE SURVEILLANCE IN CANCERS
Harnessing the immune system has emerged as a powerful therapeutic strategy in oncology. However, the limited ability of cytotoxic CD8+ T cells to infiltrate solid tumors presents a major roadblock to developing effective immunotherapy. Cytotoxic CD8+ T cells, in fact, have to infiltrate solid tumor...

In vitro phenotypic assays for Parkinson’s disease
IN VITRO PHENOTYPIC ASSAYS FOR PARKINSON’S DISEASE
The discovery and validation of novel targets are essential to fuel a healthy drug pipeline, and in vitro phenotypic assays are instrumental for delivering valid targets and promising lead molecules. View this webinar to learn more about our in vitro assay capabilities performed in clinically releva...

Advanced process development using automated micro bioreactors shortens the timeline
ADVANCED PROCESS DEVELOPMENT USING AUTOMATED MICRO BIOREACTORS SHORTENS THE TIMELINE
In the last eight years, the ambr platform has developed into a significant component of the toolset used by the biopharmaceutical industry for a wide range of upstream activities. The small-scale, high throughput nature of the systems coupled with the associated software functionality enables many ...

Phenotypic assays for CNS disease drug discovery
PHENOTYPIC ASSAYS FOR CNS DISEASE DRUG DISCOVERY
Central nervous system (CNS) disorders constitute a growing unmet medical need, with increasing prevalence of aging-related diseases (Alzheimer’s and Parkinson’s). While classical approaches in cell lines and primary neurons are valuable, (patient-derived) stem cell-based neuronal model ...

High-throughput Single Cell RNA-seq from Flow-Sorted Cells Using a Novel Miniaturized CEL-seq2 Protocol
HIGH-THROUGHPUT SINGLE CELL RNA-SEQ FROM FLOW-SORTED CELLS USING A NOVEL MINIATURIZED CEL-SEQ2 PROTOCOL
Plate-based scRNA-seq approaches are advantageous for the in-depth analysis of rare cell types and subpopulations selected by cell surface markers. This webinar will introduce a high-throughput process for generating sequencing libraries from single cells sorted into 384-well plates. Due to the redu...

Using open science to develop Pediatric Cancer Drugs
USING OPEN SCIENCE TO DEVELOP PEDIATRIC CANCER DRUGS
Childhood brain tumors are genetically distinct from adult cancers and are not a focus area for drug development. M4K Pharma is pioneering a novel open science business model to address these unprecedented “high risk” targets for a fraction of the usual cost. In this webinar, the speaker...

Art Therapy Interventions for Traumatized Children
ART THERAPY INTERVENTIONS FOR TRAUMATIZED CHILDREN
Most clinicians who work with children use art as a way to connect with their young clients, and there has been an increase in referrals for services for children who have experienced significant trauma. This topic will provide clinicians with an introduction to art therapy history and theory, a dis...

Answer the challenges of CDS Data integrity - Sterling Pharma Solutions Ltd
ANSWER THE CHALLENGES OF CDS DATA INTEGRITY - STERLING PHARMA SOLUTIONS LTD
Data integrity continues to be a hot topic for the regulatory agencies in the pharmaceutical industry. In 2012, Sterling Pharma Solutions, embarked on a mission to replace their existing chromatography data systems (CDS). It was important to have one system for the entire company spanning both labor...

Drug-Antibody Ratio (ADC) Calculations Made Easy by CE
DRUG-ANTIBODY RATIO (ADC) CALCULATIONS MADE EASY BY CE
Antibody-drug conjugates are gaining interest as new therapeutic drug targets in the BioPharma Industry. Recent developments in separations technology are enabling scientists to easily calculate antibody drug payloads of both cysteine and lysine conjugates of thermally stressed samples.

Early disease detection performing NMR - Understanding how a better analysis of metabolites in serum and urine can help
EARLY DISEASE DETECTION PERFORMING NMR - UNDERSTANDING HOW A BETTER ANALYSIS OF METABOLITES IN SERUM AND URINE CAN HELP
Quantification in body fluids like plasma/serum and urine is valuable because it provides information on endogenous compounds produced in the body as well as capturing drugs and their metabolites, in addition, lifestyle-based molecules can be recognized, be it from nutritional habits or physical act...

Biomarker endpoints for Parkinson’s disease
BIOMARKER ENDPOINTS FOR PARKINSON’S DISEASE
Therapeutic approaches for Parkinson’s disease are either focused on disease modification (a-synuclein or MPTP models) or symptom management (haloperidol or 6-OHDA models). Our scientists have validated available PD models for changes in fine motor skills, L-dopa-induced dyskinesias, drug-indu...

3D Cell Cultures and Tissue Clearing
3D CELL CULTURES AND TISSUE CLEARING
With the advent of cost-effective culturing approaches, 3D cell culture models (3D-CCMs) have been rapidly adopted for drug discovery since they provide a more physiologically relevant micro-environment; showing improved predictive utility for assessing drug efficacy and/or toxicity when compared to...

Streamlining drug discovery assays for cancer and cardiovascular disease
STREAMLINING DRUG DISCOVERY ASSAYS FOR CANCER AND CARDIOVASCULAR DISEASE
Declining R&D productivity is a key challenge in the pharmaceutical industry today. To increase the success rate of candidate drugs entering the clinical phase, companies must address the early stages of drug discovery. In lead optimization, target-based assays are still the most affordable mean...

Impact of Vicarious Traumatization on Healthcare Workers
IMPACT OF VICARIOUS TRAUMATIZATION ON HEALTHCARE WORKERS
There is a growing healthcare crisis in the ranks of healthcare providers. High demand care areas, higher patient acuities, fewer resources and more work demands deplete care providers of their personal reserves. Unidentified, this problem can manifest as joylessness, hostility, and aggression among...

From Slow Analytics Adoption to Data-Driven Sales Success
FROM SLOW ANALYTICS ADOPTION TO DATA-DRIVEN SALES SUCCESS
What’s the secret to getting widespread analytics adoption across your organization? Using a thoughtful, modern approach. Biotech giant Sanofi Genzyme influenced senior executives, managers, and field sales teams to adopt Qlik® solutions. Watch our Customer Spotlight Webinar to hear their ...

Using Reference Standards to Validate your NGS Oncology Workflow
USING REFERENCE STANDARDS TO VALIDATE YOUR NGS ONCOLOGY WORKFLOW
We are currently at an exciting precipice in clinical oncology management, where an increased rate of biomarker identification is driving the development of new targeted therapies, coupled with advances in sequencing technology capability. In the latest version release of COSMIC (v85) there are now ...

Large-Scale Brain Mapping for Reverse Engineering Brain Function
LARGE-SCALE BRAIN MAPPING FOR REVERSE ENGINEERING BRAIN FUNCTION
The Kasthuri lab is pioneering new techniques for large volume reconstructions of the fine structure of the nervous system – ‘connectomics’. In this webinar, Dr. Kasthuri will describe these developments including large volume automated electron microscopy for mapping neuronal conn...

Tackle biologics QC with Hound and Bouncer
TACKLE BIOLOGICS QC WITH HOUND AND BOUNCER
Particles muck up the quality of a drug and can shut down its production. Hound is the only tool out there that analyzes particles by size and shape then forensically identifies them by their chemical and elemental fingerprints. In minutes, you can pinpoint the culprit, track it back to the source, ...

Step up your biologics stability screening with Hunky
STEP UP YOUR BIOLOGICS STABILITY SCREENING WITH HUNKY
Many methods for studying protein stability and aggregation are qualitative, which can cause uncertainty when moving drug candidates and formulations forward. In contrast, Hunky gives you the Gibbs free energy (ΔG) of a protein, which is a powerful and quantitative indicator of the amount of u...

Advancing precision immunotherapy through next-generation sequencing of T cell receptors: Part I
ADVANCING PRECISION IMMUNOTHERAPY THROUGH NEXT-GENERATION SEQUENCING OF T CELL RECEPTORS: PART I
This webinar will review recent advancements in the application of next-generation sequencing of T cell receptor beta (TCRB) chain repertoires towards predictive and mechanistic biomarker discovery for cancer immunotherapy. Dr. Looney will focus on immunotherapy biomarker applications of a long-ampl...

Precision Medicine 2018
PRECISION MEDICINE 2018
Our 3rd Annual Precision Medicine Virtual Conference is now available On Demand! Precision Medicine 2018 will continue the dialogue and provide updates on new efforts in drug discoveries, developments in FDA regulatory structures, and the integration of genetics on disease progression. Precision Med...

CRISPR for Disease Detection and the Future of Accessible Healthcare
CRISPR FOR DISEASE DETECTION AND THE FUTURE OF ACCESSIBLE HEALTHCARE
This webinar explores the technology behind Mammoth Biosciences’ newly announced CRISPR-powered diagnostics platform, giving insight to CRISPR and how it works for disease detection. In this webinar, Ashley will first give an explanation of what CRISPR does and how it’s been used up unti...

Exon-level array: Bridging the gap between chromosomal microarray and next-gen sequencing
EXON-LEVEL ARRAY: BRIDGING THE GAP BETWEEN CHROMOSOMAL MICROARRAY AND NEXT-GEN SEQUENCING
Current exon-level arrays and NGS techniques for CNV detection are plagued with a high number of false-positive calls and are challenging from a cost perspective when verifying numerous exon aberrations with orthogonal methods. Relevant gene lists continue to grow such that custom del/dup arrays out...

Using bioactivity profiling to support the progression of phenotypic hits
USING BIOACTIVITY PROFILING TO SUPPORT THE PROGRESSION OF PHENOTYPIC HITS
Bioactivity profiling has been traditionally used to assess the selectivity of new drug candidates in the context of target-based approaches, where pharmacological selectivity is a key requirement. Phenotypic screening provides hit molecules where the only initial constraint is activity in a functio...

The Neuroscience of Body Clocks (Online Symposium)
THE NEUROSCIENCE OF BODY CLOCKS (ONLINE SYMPOSIUM)
This online symposium will explore the neuroscience underpinning the daily rhythms of the brain. Specifically, the event will focus on the neurobiology of circadian rhythms, our 24-hour sleep/wake cycle. Leading researchers will discuss their work investigating the neural circuitry that wakes us up ...

Sequence Your Biopharma N-Glycans in as Little as 1 Hour
SEQUENCE YOUR BIOPHARMA N-GLYCANS IN AS LITTLE AS 1 HOUR
If you are working with N-linked carbohydrates of glycoproteins in the biopharmaceutical or biomedical fields, imagine the amount of time you can save with either semi- or fully-automated CE methods providing you information in just 60-120 minutes. Comprehensive analysis of the N-linked carbohydrate...

Automated assessment of Liver and Cardiac toxicities in lead optimisation, using biochemical and human iPS cell assays
AUTOMATED ASSESSMENT OF LIVER AND CARDIAC TOXICITIES IN LEAD OPTIMISATION, USING BIOCHEMICAL AND HUMAN IPS CELL ASSAYS
In this two-part webinar, both automation of P450 (CYP) assays and the automatization of cellular differentiation processes and compound testing using human induced pluripotent stem cells based assays was covered.  Metabolism of drugs is a key factor in compound toxicity, and automated assays w...

How to make digital work in medtech
HOW TO MAKE DIGITAL WORK IN MEDTECH
The rise of mobile devices and apps, not to mention the involvement of non-medical technology players, is creating a wave of irrevocable digital change for medtech.
It’s transforming how the sector reaches and engages with its stakeholders and customers, and in doing so provides vital o...

Investigating the role of microRNAs in pancreatic cancer progression
INVESTIGATING THE ROLE OF MICRORNAS IN PANCREATIC CANCER PROGRESSION
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate of approximately 6%. Despite recent efforts in developing novel therapies, chemotherapy remains the standard of care for advanced pancreatic cancer patients. MicroRNAs (miRNAs) are short non-coding RNAs that act ...

CANCER IMMUNOTHERAPY: EXPERIMENTAL MODELS AND APPROACHES
CANCER IMMUNOTHERAPY: EXPERIMENTAL MODELS AND APPROACHES
The mammalian immune system has developed surveillance mechanisms that can detect cancerous cells. However successful tumor cells have evolved strategies to evade detection. Current therapeutic strategies focus on improving cancer cell recognition and tumor elimination. Both immunocompetent and immu...

Diagnostic and Therapeutic Patent and License Strategies
DIAGNOSTIC AND THERAPEUTIC PATENT AND LICENSE STRATEGIES
Dr. Lisa Haile presents this webinar exploring issues and strategies for diagnostic and therapeutic patents and licenses. This webinar will address questions such as: Are diagnostic tests patentable? What are the effects of the Alice ruling and the Myriad Genetics case on patents? What strat...

Raman spectroscopy measurements during Bioprocessing
RAMAN SPECTROSCOPY MEASUREMENTS DURING BIOPROCESSING
Raman spectroscopy has been seen as the spectroscopic tool used in bioprocessing to monitor and control cell metabolism to optimize quality and yield of titer. This is due to Raman’s insensitivity to water and the ability to analyze samples without manipulation. However, there are certain chal...

Development and Manufacturing of Recombinant Nanoparticle Vaccines
DEVELOPMENT AND MANUFACTURING OF RECOMBINANT NANOPARTICLE VACCINES
A recombinant vaccine technology platform based on highly purified, properly-folded protein antigens in stable well-defined Nanoparticles, enabling the efficient and safe manufacture of vaccines against highly pathogenic targets. Nanoparticles are intrinsically immunogenic, producing both durable ne...

Fast and complete cyclic peptide metabolite detection and characterization by LC-MS
FAST AND COMPLETE CYCLIC PEPTIDE METABOLITE DETECTION AND CHARACTERIZATION BY LC-MS
Cyclic peptides have emerged as next-generation therapeutic agents, due to their unique structure and potential biological function. However, the study of cyclic peptide drug metabolism by LC-MS is challenging because these therapeutics typically do not generate high quality and interpretable fragme...

EFIRM Liquid Biopsy (eLB)
EFIRM LIQUID BIOPSY (ELB)
The advent of personalized medicine employing molecularly targeted therapies has markedly changed the treatment of cancer in the past decade. The liquid biopsy is a rapidly emerging field to address this unmet clinical need as diagnostics based on cell-free circulating tumor DNA (ctDNA) can be ...